ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Product Name
- ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- CAS No.
- 518990-21-1
- Chemical Name
- ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Synonyms
- ethyl 1H,4H,6H,7H-pyrano[4,3-c]pyrazole-3-carboxylate;ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate;1,4,6,7-Tetrahydro-pyrano[4,3-c]pyrazole-3-carboxylic acid ethyl ester;Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro-, ethyl ester
- CBNumber
- CB72490800
- Molecular Formula
- C9H12N2O3
- Formula Weight
- 196.2
- MOL File
- 518990-21-1.mol
ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-0037886
- Product name
- Ethyl1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- CS-0037886
- Product name
- Ethyl1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- CS-0037886
- Product name
- Ethyl1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 175825
- Product name
- Ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-0037886
- Product name
- Ethyl1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate
- Packaging
- 5g
- Price
- $467
- Updated
- 2021/12/16
ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate Chemical Properties,Usage,Production
Synthesis
857177-01-6
518990-21-1
Ethyl 2-oxo-2-(4-oxotetrahydro-2H-pyran-3-yl)acetate (1.1 kg) was used as starting material and dissolved in glacial acetic acid (1.0 kg). The reaction temperature was controlled in the range of 20-30 °C and hydrazine hydrate (910 g, 14.4 mol, 2.9 equiv.) was added slowly dropwise. After the dropwise addition, the reaction was maintained at this temperature and stirred overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, water (10 L) and ethyl acetate (5 L) were added to the reaction mixture. The pH was adjusted to 8-9 with solid sodium carbonate and after completion of the adjustment, stirring was continued for 30 min, followed by standing and layering. The aqueous layer was extracted twice with ethyl acetate (5 L × 2). All organic layers were combined and washed with brine (5 L). The organic phase was concentrated under reduced pressure until no significant liquid evaporated, and was pulped by adding petroleum ether (2 L). After filtration, ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate (915 g, UPLC purity: 99%) was obtained as white crude product.
References
[1] Patent: CN108546266, 2018, A. Location in patent: Paragraph 0045-0047
ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate manufacturers
- Product
- ethyl 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylate 518990-21-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-12