4-Chloro-2-cyano-6-methylpyrimidine
- Product Name
- 4-Chloro-2-cyano-6-methylpyrimidine
- CAS No.
- 104711-65-1
- Chemical Name
- 4-Chloro-2-cyano-6-methylpyrimidine
- Synonyms
- 4-Chloro-6-Methylpicolinonitrile;4-Chloro-2-cyano-6-methylpyridine;4-Chloro-2-cyano-6-methylpyrimidine;4-chloro-methyl-pyridine -2-cabonitrile;4-Chloro-6-methyl-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 4-chloro-6-methyl-;4-Chloro-2-cyano-6-methylpyrimidine ISO 9001：2015 REACH
- CBNumber
- CB72490835
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 104711-65-1.mol
4-Chloro-2-cyano-6-methylpyrimidine Property
- Melting point:
- 78-79 °C
- Boiling point:
- 250.1±35.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.72±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0043749
- Product name
- 4-CHLORO-2-CYANO-6-METHYLPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.1
- Updated
- 2021/12/16
- Product number
- 128490
- Product name
- 4-Chloro-6-methylpicolinonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $1692
- Updated
- 2021/12/16
- Product number
- A242575
- Product name
- 4-Chloro-6-methylpicolinonitrile
- Purity
- 98%
- Packaging
- 100mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- A242575
- Product name
- 4-Chloro-6-methylpicolinonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- A242575
- Product name
- 4-Chloro-6-methylpicolinonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $327
- Updated
- 2021/12/16
4-Chloro-2-cyano-6-methylpyrimidine Chemical Properties,Usage,Production
Synthesis
696-08-2
7677-24-9
104711-65-1
General procedure for the preparation of 4-chloro-6-methylpyridinecarbonitrile: 4-chloro-2-methylpyridine-N-oxide (8.97 g, 62.5 mmol, 1.00 eq.) was dissolved in dichloromethane (CH2Cl2) and dried with anhydrous magnesium sulfate (MgSO4). The resulting solution was transferred to a pre-flame-dried round-bottomed flask and dichloromethane was replenished to a total volume of 188 mL. Subsequently, trimethylcyanosilane (TMS-cyanide, 10 mL, 75 mmol, 1.2 equiv.) was added and the reaction mixture was stirred for 15 min. Dimethylcarbamoyl chloride (6.9 mL, 75 mmol, 1.2 eq.) was added slowly and dropwise over 20 minutes and the reaction continued to be stirred for 24 hours. After that, 1 equivalent of trimethylcyanosilane and dimethylcarbamoyl chloride was added additionally and the reaction was continued with stirring for 72 hours. After completion of the reaction, the reaction solution was adjusted to alkaline with 10% potassium carbonate (K2CO3) solution and extracted with dichloromethane (3×). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography on silica gel afforded 7.2 g (75% yield) of the target compound 4-chloro-6-methylpyridinecarbonitrile as a white solid. NMR hydrogen spectrum (400 MHz, DMSO-d6) δ 8.13 (d, J = 1.6 Hz, 1H), 7.82 (d, J = 1.7 Hz, 1H), 2.52 (s, 3H); electrospray mass spectrometry (ES-MS) [M + 1]+: m/z calculated value.
References
[1] Patent: WO2016/102493, 2016, A1. Location in patent: Page/Page column 86; 87
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5072 - 5085
[3] Patent: WO2012/118563, 2012, A2. Location in patent: Page/Page column 135-136
[4] Patent: WO2015/200682, 2015, A1. Location in patent: Paragraph 00468
[5] Tetrahedron Letters, 2017, vol. 58, # 36, p. 3554 - 3558
4-Chloro-2-cyano-6-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-2-cyano-6-methylpyrimidine manufacturers
- Product
- 4-Chloro-2-cyano-6-methylpyrimidine 104711-65-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-31