ChemicalBook > CAS DataBase List > tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
- Product Name
- tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
- CAS No.
- 345311-03-7
- Chemical Name
- tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
- Synonyms
- 7-Boc-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine;7-N-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine;tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H);_x000D_7-Boc-5，6，7，8-tetrahydroimidazo[1，2-a]pyrazine;tert-butyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-7-carboxylate;tert-butyl 6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carboxylate;tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate ;5,6-Dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester;Imidazo[1,2-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB72491685
- Molecular Formula
- C11H17N3O2
- Formula Weight
- 223.27
- MOL File
- 345311-03-7.mol
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tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate Property
- Density
- 1.20
- storage temp.
- 2-8°C
- Appearance
- Off-white to light brown Solid
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N-Bromosuccinimide Price
TRC
- Product number
- B902673
- Product name
- tert-Butyl5,6-Dihydroimidazo[1,2-A]pyrazine-7(8H)-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- B902673
- Product name
- tert-Butyl5,6-Dihydroimidazo[1,2-A]pyrazine-7(8H)-carboxylate
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0385393
- Product name
- TERT-BUTYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZINE-7-(8H)-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.87
- Updated
- 2021/12/16
AK Scientific
- Product number
- W5613
- Product name
- tert-Butyl5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
- Packaging
- 5g
- Price
- $537
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 070041
- Product name
- tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $832
- Updated
- 2021/12/16
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tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate Chemical Properties,Usage,Production
Synthesis
345311-02-6
345311-03-7
The general procedure for the synthesis of 7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine from the compound (CAS: 345311-02-6) is as follows: to a solution of N-(2-chloroethyl)-N-(1-{[2-(trimethylmethylsilyl)ethoxy]methyl}-1H-imidazol-2-ylmethyl)carbamate (description 162, 2.52 g, 2.5 mmol. 6.5 mmol) to a solution of tetrahydrofuran (50 mL) was added tetrabutylammonium fluoride (1M solution of tetrahydrofuran, 7.1 mL, 7.1 mmol) and the reaction mixture was heated to reflux for 1.5 hours. Subsequently, tetrabutylammonium fluoride (1M tetrahydrofuran solution, 7.1 mL, 7.1 mmol) was added again and the reaction mixture was continued to be heated to reflux for 20 hours. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation under reduced pressure. The residue was purified by silica gel fast column chromatography using CH2Cl2/MeOH (97:3) as eluent to give 7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (505 mg, 35% yield). Mass spectrum (electrospray positive ion mode) m/z: 224 ([M+1]+).
References
[1] Patent: US2003/236250, 2003, A1. Location in patent: Page 40
tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate Preparation Products And Raw materials
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Preparation Products
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345311-03-7, tert-butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate Related Search:
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