ChemicalBook > CAS DataBase List > 3-Bromo-5-fluoro-2-methylaniline

3-Bromo-5-fluoro-2-methylaniline

Product Name
3-Bromo-5-fluoro-2-methylaniline
CAS No.
502496-36-8
Chemical Name
3-Bromo-5-fluoro-2-methylaniline
Synonyms
2-Methyl-3-bromo-5-fluoroaniline;3-Bromo-5-fluoro-2-methylaniline;2-Amino-6-bromo-4-fluorotoluene 98%;3-Bromo-5-fluoro-2-methylphenylamine;3-Bromo-5-fluoro-2-methylbenzenamine;BenzenaMine, 3-broMo-5-fluoro-2-Methyl-;3-Bromo-5-fluoro-2-methylaniline ISO 9001：2015 REACH
CBNumber
CB72500781
Molecular Formula
C7H7BrFN
Formula Weight
204.04
MOL File
502496-36-8.mol
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3-Bromo-5-fluoro-2-methylaniline Property

Boiling point:
259℃
Density 
1.589
Flash point:
110℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.36±0.10(Predicted)
form 
powder
color 
Light orange to light brown
InChI
InChI=1S/C7H7BrFN/c1-4-6(8)2-5(9)3-7(4)10/h2-3H,10H2,1H3
InChIKey
DSYSVUWIAUMZDQ-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC(Br)=C1C
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B700330
Product name
3-Bromo-5-fluoro-2-methylaniline
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
3730-B-09
Product name
2-Amino-6-bromo-4-fluorotoluene
Packaging
1g
Price
$184
Updated
2021/12/16
AK Scientific
Product number
Z4802
Product name
3-Bromo-5-fluoro-2-methylaniline
Packaging
5g
Price
$272
Updated
2021/12/16
Matrix Scientific
Product number
089936
Product name
3-Bromo-5-fluoro-2-methylaniline
Purity
95+%
Packaging
5g
Price
$363
Updated
2021/12/16
SynQuest Laboratories
Product number
3730-B-09
Product name
2-Amino-6-bromo-4-fluorotoluene
Packaging
5G
Price
$384
Updated
2021/12/16
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3-Bromo-5-fluoro-2-methylaniline Chemical Properties,Usage,Production

Synthesis

502496-33-5

502496-36-8

General procedure for the synthesis of 2-methyl-3-bromo-5-fluoroaniline from 2-bromo-4-fluoro-6-nitrotoluene: [00402] Ammonium chloride (571 mg, 10.7 mmol) was added to a mixture of 1-bromo-5-fluoro-2-methyl-3-nitrobenzene (500 mg, 2.14 mmol) and iron powder (0.6 g, 10.68 mmol). Water (24 mL) and ethanol (24 mL) were subsequently added. The reaction mixture was refluxed for 5 h. After completion of the reaction, it was filtered through diatomaceous earth and the filter cake was washed with ethanol (100 mL) and ethyl acetate (100 mL). The organic solvent was removed in vacuum to give an aqueous solution, which was extracted with dichloromethane (3 x 30 mL). The organic layer was separated and concentrated to afford the crude product 3-bromo-5-fluoro-2-methylaniline (390 mg, 1.87 mmol, 87.7% yield), which was analyzed by nuclear magnetic resonance (NMR) and showed good purity and could be used in the next reaction without further purification. [00403] 1H NMR (DMSO-d6): δ 6.60 (dd, J = 2.8 and 8.4 Hz, 1H), 6.42 (dd, J = 2.8 and 11.6 Hz, 1H), 5.54 (bs, 2H), 2.09 (s, 3H).

References

[1] Organic Letters, 2017, vol. 19, # 24, p. 6518 - 6521
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Patent: WO2015/79251, 2015, A1. Location in patent: Paragraph 00402; 00403
[4] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 155
[5] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0279; 0280

3-Bromo-5-fluoro-2-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-5-fluoro-2-methylaniline manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
3-Bromo-5-fluoro-2-methylaniline 502496-36-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞98% by HPLC
Supply Ability
200kg/month
Release date
2025-10-10
Career Henan Chemical Co
Product
3-Bromo-5-fluoro-2-methylaniline 502496-36-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

502496-36-8, 3-Bromo-5-fluoro-2-methylanilineRelated Search:

3-Benzyloxy-5-chlorophenylaMine 2-Nitro-3,4,6-trifluoroaniline 3-BROMO-1,2-DIAMINO-5-FLUOROBENZENE 3,5-DICHLORO-4-(TRIFLUOROMETHYL)ANILINE 3-(Difluoromethoxy)-2-fluoroaniline 3,4-difluoro-2-methylaniline 2-methyl-3-(trifluoromethoxy)aniline 3-bromo-5-isopropoxybenzenamine 3-Iodo-4-(trifluoromethyl)aniline 3,4-Dichloro-2-methylaniline 3-(Difluoromethoxy)aniline 2-METHOXY-4-(TRIFLUOROMETHYL)ANILINE

  • 3-Bromo-5-fluoro-2-methylaniline
  • 3-Bromo-5-fluoro-2-methylbenzenamine
  • 3-Bromo-5-fluoro-2-methylphenylamine
  • BenzenaMine, 3-broMo-5-fluoro-2-Methyl-
  • 2-Methyl-3-bromo-5-fluoroaniline
  • 2-Amino-6-bromo-4-fluorotoluene 98%
  • 3-Bromo-5-fluoro-2-methylaniline ISO 9001：2015 REACH
  • 502496-36-8
  • Intermediate