6-Bromo-7-fluoroquinoline
- Product Name
- 6-Bromo-7-fluoroquinoline
- CAS No.
- 127827-52-5
- Chemical Name
- 6-Bromo-7-fluoroquinoline
- Synonyms
- 6-Bromo-7-fluoroquinoline;Quinoline, 6-bromo-7-fluoro-;6-Bromo-7-fluoroquinoline ISO 9001：2015 REACH
- CBNumber
- CB72500857
- Molecular Formula
- C9H5BrFN
- Formula Weight
- 226.05
- MOL File
- 127827-52-5.mol
6-Bromo-7-fluoroquinoline Property
- Boiling point:
- 295.7±20.0 °C(Predicted)
- Density
- 1.647±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.01±0.17(Predicted)
- form
- solid
- color
- Off White
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- B700220
- Product name
- 6-Bromo-7-fluoroquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- BP-30018
- Product name
- 6-BROMO-7-FLUOROQUINOLINE
- Purity
- 97%
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- PC448001
- Product name
- 6-Bromo-7-fluoroquinoline
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- PC448001
- Product name
- 6-Bromo-7-fluoroquinoline
- Packaging
- 5g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- BP-30018
- Product name
- 6-BROMO-7-FLUOROQUINOLINE
- Purity
- 97%
- Packaging
- 5G
- Price
- $193
- Updated
- 2021/12/16
6-Bromo-7-fluoroquinoline Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Solid
Synthesis
656-65-5
56-81-5
127827-52-5
General procedure for the synthesis of 6-bromo-7-fluoroquinoline from 4-bromo-3-fluoroaniline and glycerol: Intermediate 2: (7-fluoroquinolin-6-yl)methylamine Step 1: Synthesis of 6-bromo-7-fluoroquinoline: 4-bromo-2-fluoroaniline (10 g, 52.62 mmol), ferrous sulfate (3.33 g, 11.97 mmol) and glycerol (15.78 mL) were mixed. Concentrated sulfuric acid (9.15 mL) was added slowly and the reaction mixture was heated to 140 °C. After 12 hours of reaction, the mixture was cooled to 0 °C and the pH was adjusted to 10-12 with 10% sodium hydroxide solution.The reaction mixture was filtered through diatomaceous earth and washed with ethyl acetate to separate the organic and aqueous layers. The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by column chromatography (eluent: ethyl acetate/petroleum ether) to give the title compound as a white solid (4.9 g, 44% yield). 1H-NMR (δppm, CDCl3, 400MHz): δ 8.96 (dd, J=4.3,2.7Hz, 1H), 8.15 (m, 2H), 7.81 (d, J=9.5Hz, 1H), 7.42 (dd, J=8.3,4.3Hz, 1H).
References
[1] Patent: CN105968115, 2016, A. Location in patent: Paragraph 0560-0562
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 4281 - 4290
[3] Patent: US2007/265272, 2007, A1. Location in patent: Page/Page column 31-32
[4] Patent: WO2013/144737, 2013, A2. Location in patent: Paragraph 252
[5] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0509
6-Bromo-7-fluoroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-7-fluoroquinoline Suppliers
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View Lastest Price from 6-Bromo-7-fluoroquinoline manufacturers
- Product
- 6-Bromo-7-fluoroquinoline 127827-52-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18