2-chlorothiazolo[5,4-b]pyridine
- Product Name
- 2-chlorothiazolo[5,4-b]pyridine
- CAS No.
- 91524-96-8
- Chemical Name
- 2-chlorothiazolo[5,4-b]pyridine
- Synonyms
- 2-chloro-[1,3]thiazolo[5,4-b]pyridine;2-chlorothiazolo[5,4-b]pyridine;Thiazolo[5,4-b]pyridine, 2-chloro-;2-chlorothiazolo[5,4-b]pyridine Purity:97%min
- CBNumber
- CB72506071
- Molecular Formula
- C6H3ClN2S
- Formula Weight
- 170.62
- MOL File
- 91524-96-8.mol
2-chlorothiazolo[5,4-b]pyridine Property
- Boiling point:
- 263.5±13.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 0.17±0.50(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H3ClN2S/c7-6-9-4-2-1-3-8-5(4)10-6/h1-3H
- InChIKey
- TVHRCGOWLCQJKU-UHFFFAOYSA-N
- SMILES
- C12SC(Cl)=NC1=CC=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FC141296
- Product name
- 2-Chlorothiazolo[5,4-b]pyridine
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FC141296
- Product name
- 2-Chlorothiazolo[5,4-b]pyridine
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FC141296
- Product name
- 2-Chlorothiazolo[5,4-b]pyridine
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 119667
- Product name
- 2-Chlorothiazolo[5,4-b]pyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- HCH0363740
- Product name
- 2-CHLOROTHIAZOLO[5,4-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.63
- Updated
- 2021/12/16
2-chlorothiazolo[5,4-b]pyridine Chemical Properties,Usage,Production
Synthesis
39856-58-1
140-89-6
91524-96-8
2-Bromo-3-aminopyridine (1.14 g, 6.59 mmol) and potassium ethylxanthate (2.324 g, 14.50 mmol) were used as starting materials, which were dissolved in anhydrous dimethylformamide (4 mL) and heated to react for 15 hours at 130 °C. After the reaction was completed, it was cooled to room temperature and the reaction mixture was diluted with water (150 mL). 5N hydrochloric acid (4 mL) was added and after stirring, the intermediate precipitated as a pale yellow solid, which was collected by filtration. The resulting solid was suspended in preheated ethyl acetate (200 mL) and dried by adding magnesium sulfate. After filtration, the filter cake was washed with preheated ethyl acetate (200 mL). The organic phases were combined and concentrated to dryness under reduced pressure. The residue was suspended in dichloromethane (50 mL), sulfuryl chloride (20 mL, 247 mmol) was added and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the residue was partitioned between ethyl acetate (200 mL), ice (50 mL), water (100 mL) and saturated sodium bicarbonate solution (60 mL). The organic phase was separated, dried over magnesium sulfate and concentrated to dryness under reduced pressure. Finally, purification by silica gel column chromatography (dichloromethane to ethyl acetate gradient elution) afforded the target product 2-chlorothiazolo[5,4-b]pyridine (0.120 g, 0.703 mmol, 10.7% yield).
References
[1] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0494
2-chlorothiazolo[5,4-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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