Δ2-Cefuroxime Axetil

Product Name: Δ2-Cefuroxime Axetil
CAS No.: 123458-61-7
Chemical Name: Δ2-Cefuroxime Axetil
Synonyms: Δ2-Cefuroxime Axetil;Cefuroxim Impurity 34;Cefuroxim Impurity 10;Delta2-Cefuroxime axetil;Cefuroxim axetil impurity A;Cefuroxime Axetil EP Impurity A;Cefuroxime Axetil Impurities (EP);Cefuroxime Axetil Impurity A (EP);(6R,7R)-1-acetoxyethyl 3-((carbamoyloxy)methyl);Cefuroxime Axetil Impurity A (EP)（Δ3-Cefuroxime Axetil）
CBNumber: CB72508510
Molecular Formula: C20H22N4O10S
Formula Weight: 510.47
MOL File: 123458-61-7.mol

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Δ2-Cefuroxime Axetil Property

Melting point:: 64-71°C
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.33±0.60(Predicted)
color: White to Pale Yellow
Stability:: Hygroscopic
Major Application: pharmaceutical (small molecule)
InChIKey: AQVGUOHUYICCIZ-WDVFJNCVSA-N
SMILES: S1[C@H]2N(C(C(=C1)COC(=O)N)C(=O)OC(OC(=O)C)C)C(=O)[C@H]2NC(=O)\C(=N/OC)\c3[o]ccc3

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1098231
Product name: Cefuroxime Axetil Delta-3-Isomers
Packaging: 10mg
Price: $1200
Updated: 2025/07/31

TRC

Product number: C248070
Product name: Δ2-CefuroximeAxetil(CefuroximeAxetilDelta-3Isomer)
Packaging: 1mg
Price: $210
Updated: 2021/12/16

TRC

Product number: C248070
Product name: Δ2-CefuroximeAxetil(CefuroximeAxetilDelta-3Isomer)
Packaging: 2mg
Price: $410
Updated: 2021/12/16

AK Scientific

Product number: 7515DU
Product name: delta2-Cefuroximeaxetil
Packaging: 5mg
Price: $1737
Updated: 2021/12/16

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Δ2-Cefuroxime Axetil Chemical Properties,Usage,Production

Uses

It is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.

Uses

Δ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.

Synthesis

The ethyl acetate solution of ??2-cefuroxime was concentrated to 30% under vacuum -0.99 MPa to obtain ??2-cefuroxime concentrate. To 25 ml of isopropyl ether or petroleum ether, add 0.2 g of ??2- cefuroxime crystalline seed and stir rapidly to obtain cefuroxime isopropyl ether or ??2- cefuroxime petroleum ether suspension. In the ??2- cefuroxime isopropyl ether or ??2- cefuroxime petroleum ether suspension, add the above ??2- cefuroxime concentrate and 800 ml of isopropyl ether or petroleum ether solution at the same time and uniformly over a period of 2.5h, and then raise the crystals for 1h and then filter. The crystals obtained by filtration were washed with 40 ml of ethyl acetate isopropyl ether or ethyl acetate petroleum ether solution in the ratio of 1:5 by volume, and then washed with 40 ml of isopropyl ether or petroleum ether, and then dried in a vacuum at 40?? C., obtaining a white product. The white product was prepared into amorphous ?2-2-cephemofuroxin ester by spray drying, which can then be made into oral preparations such as capsules, tablets, granules or dispersible tablets.

Δ2-Cefuroxime Axetil Preparation Products And Raw materials

Raw materials

Preparation Products

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Δ2-Cefuroxime Axetil Suppliers

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123458-61-7, Δ2-Cefuroxime AxetilRelated Search:

Cefuroxime Sodium EP Impurity G (αZ)-α-(MethoxyiMino)-N-[(5aR,6R)-1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl]-2-furanacetaMide Cefuroxime 1-acetoxyethyl ester

Δ2-Cefuroxime Axetil

(6R,7R)-3-[[(AMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-furanyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic Acid 1-(Acetyloxy)ethyl Ester

[6R-[6α, 7β(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester

Cefuroxime Axetil EP Impurity A

Cefuroxime Axetil Impurity A (EP)

Cefuroxime Axetil Impurities (EP)

Cefuroxime Impurity 34(Cefuroxime Axetil EP Impurity A)

(6R,7R)-1-acetoxyethyl 3-((carbamoyloxy)methyl)

Cefuroxime Axetil Impurity A (EP)（Δ3-Cefuroxime Axetil）

1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate

Δ2-Cefuroxime Axetil (Cefuroxime Axetil Delta-3 Isomer)

5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-

Cefuroxim Impurity 34

Cefuroxim axetil impurity A

1-acetoxyethyl (6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate

(6R,7R)-1-Acetoxyethyl 3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate (Cefuroxime Impurity)

Cefuroxim Impurity 10

Delta2-Cefuroxime axetil

delta2-Cefuroxime Axetil (Cefuroxime Axetil Delta-3 Isomer)

123458-61-7

Chiral Reagents, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds

Chiral Reagents

Drug Analogues

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds