ChemicalBook > CAS DataBase List > Hydromorphone hydrochloride

Hydromorphone hydrochloride

Product Name
Hydromorphone hydrochloride
CAS No.
71-68-1
Chemical Name
Hydromorphone hydrochloride
Synonyms
HYDROMORPHONE HCL;dilaudidhydrochloride;XHILEZUETWRSHC-NRGUFEMZSA-N;Hydromorphine hydrochloride;HYDROMORPHONE HYDROCHLORIDE;HYDROMORPHONEHYDROCHLORIDE,USP;dihydromorphinonehydrochloride;Hydromorphone hydrochloride salt;Morphinone, dihydro-, hydrochloride;hydromorphone hydrochloride solution
CBNumber
CB7250921
Molecular Formula
C17H20ClNO3
Formula Weight
321.8
MOL File
71-68-1.mol
More
Less

Hydromorphone hydrochloride Property

Melting point:
>280°C (dec.)
alpha 
D25 -133°
Density 
1.1451 (rough estimate)
refractive index 
1.6470 (estimate)
storage temp. 
2-8°C
solubility 
H2O: >10 mg/mL
form 
A crystalline solid
EPA Substance Registry System
Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride (1:1), (5.alpha.) (71-68-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
16-36/37-45
RIDADR 
UN 1230 3/PG 2
WGK Germany 
3
RTECS 
QD2625000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2939110000
Toxicity
LD50 in mice (mg/kg): 61-96 i.v. (Buchwald, Eadie)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5136
Product name
Hydromorphone hydrochloride
Packaging
50mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
1323000
Product name
Hydromorphone hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$581
Updated
2024/03/01
Cayman Chemical
Product number
26515
Product name
Hydromorphone (hydrochloride)
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
26515
Product name
Hydromorphone (hydrochloride)
Packaging
25mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
H5136
Product name
Hydromorphone hydrochloride
Packaging
250mg
Price
$363
Updated
2024/03/01
More
Less

Hydromorphone hydrochloride Chemical Properties,Usage,Production

Description

Hydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.

Chemical Properties

White Solid

Uses

Analgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).

Biochem/physiol Actions

Narcotic opiate analgesic; μ opioid receptor agonist.

Clinical Use

Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.

Safety Profile

Poison by subcutaneous and intravenous routes. Experimental teratogenic effects. A powerful analgesic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also MORPHINE.

Drug interactions

Potentially hazardous interactions with other drugs
Alcohol: can cause dose dumping with sustained release preparations.
Analgesics: possible opioid withdrawal effects with buprenorphine and pentazocine.
Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Metabolism

Hydromorphone undergoes extensive firstpass metabolism. It is extensively metabolised by glucuronidation in the liver and excreted in the urine mainly as conjugated hydromorphone, dihydroisomorphine, and dihydromorphine.

Hydromorphone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Hydromorphone hydrochloride Suppliers

Yichang people Fook Pharmaceutical Co., Ltd.
Tel
0717-6345091,0717-6345030
Fax
0717-6345002
Email
mail@ycrenfu.com.cn
Country
China
ProdList
6
Advantage
60
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Alfa Chemistry
Tel
+1-5166625404
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
21317
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
11437
Advantage
58
More
Less

View Lastest Price from Hydromorphone hydrochloride manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
hydromorphone hydrochloride 71-68-1
Price
US $12.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000Tons
Release date
2023-05-05
Hebei Best Biological Technology Co., Ltd
Product
hydromorphone hydrochloride 71-68-1
Price
US $200.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000t/month
Release date
2022-11-09
Hebei Nafu Technology Co. , Ltd.
Product
Hydromorphone hydrochloride 71-68-1
Price
US $12.00/g
Min. Order
1g
Purity
99%
Supply Ability
200tons
Release date
2022-09-27

71-68-1, Hydromorphone hydrochlorideRelated Search:


  • morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-,hydrochloride,(5’-alpha
  • hydromorphone hydrochloride--dea*schedule ii item
  • HYDROMORPHONE HYDROCHLORIDE METHANOL*SOL UTION
  • XHILEZUETWRSHC-NRGUFEMZSA-N
  • HYDROMORPHONE HYDROCHLORIDE OPIATE ANALG ESIC
  • (5α)-4,5-epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride
  • hydromorphone hydrochloride solution
  • HYDROMORPHONEHYDROCHLORIDE,USP
  • Hydromorphine hydrochloride
  • Morphinan-6-one, 4,5.alpha.-epoxy-3-hydroxy-17-methyl-, hydrochloride
  • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5.alpha.)-
  • Morphinone, dihydro-, hydrochloride
  • HYDROMORPHONE HCL
  • HYDROMORPHONE HYDROCHLORIDE
  • HydroMorphone Hydrochloride (CII), USP
  • Hydromorphone Hydrochloride CII (50 mg)
  • Morphinan-6-one,4,5-epoxy-3-hydroxy-17-Methyl-, hydrochloride (1:1), (5a)-
  • 4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-onehydrochloride
  • dihydromorphinonehydrochloride
  • dilaudidhydrochloride
  • Hydromorphone hydrochloride salt
  • (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one hydrochloride
  • Hydrocodone Hydrogen Tartrate 2.5-Hydrate Impurity K as Hydrochloride
  • Hydrocodone Hydrogen Tartrate 2.5-Hydrate EP Impurity K as Hydrochloride
  • 71-68-1
  • HU - HZ
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • Analytical Standards
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals