Desmosterol-d6
- Product Name
- Desmosterol-d6
- CAS No.
- 1246298-67-8
- Chemical Name
- Desmosterol-d6
- Synonyms
- Desmosterol-d6;[2H6]-Desmosterol;24-dehydro Cholesterol-d6;cholesta-5,24-dien-3-ol-d6;cholesta-5,24-dien-3β-ol-d6;Desmosterol-26,26,26,27,27,27-d6;CHOLESTA-5,24-DIEN-3-OL-D6;DESMOSTEROL-D6
- CBNumber
- CB72512379
- Molecular Formula
- C27H44O
- Formula Weight
- 384.63766
- MOL File
- 1246298-67-8.mol
Desmosterol-d6 Property
- Melting point:
- 114-116°C
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- color
- Off-White to Light Beige
Safety
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- 26777
- Product name
- 24-dehydro Cholesterol-d6
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>6</sub>)
- Packaging
- 500μg
- Price
- $134
- Updated
- 2026/04/30
- Product number
- 26777
- Product name
- 24-dehydro Cholesterol-d6
- Purity
- ≥99%deuteratedforms(d<sub>1</sub>-d<sub>6</sub>)
- Packaging
- 1mg
- Price
- $253
- Updated
- 2026/04/30
- Product number
- 26777
- Product name
- 24-dehydro Cholesterol-d6
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 26777
- Product name
- 24-dehydro Cholesterol-d6
- Packaging
- 1mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- D296862
- Product name
- Desmosterol-d6
- Packaging
- 1mg
- Price
- $245
- Updated
- 2021/12/16
Desmosterol-d6 Chemical Properties,Usage,Production
Description
24-dehydro Cholesterol-d6 is intended for use as an internal standard for the quantification of 24-dehydro cholesterol by GC- or LC-MS. 24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.
Uses
A labelled metabolite of Cholesterol (C432501).
References
[1] DANIEL HUSTER. Desmosterol may replace cholesterol in lipid membranes.[J]. Biophysical journal, 2005: 1838-1844. DOI: 10.1529/biophysj.104.048926
[2] MAURICE JANSEN. What dictates the accumulation of desmosterol in the developing brain[J]. FASEB Journal, 2012, 27 3: 865-870. DOI: 10.1096/fj.12-211235
[3] MAURA HEVERIN. Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2007, 27 10: 2191-2197. DOI: 10.1161/atvbaha.107.149823
[4] NATHANAEL J SPANN. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.[J]. Cell, 2012, 151 1: 138-152. DOI: 10.1016/j.cell.2012.06.054
Desmosterol-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
Desmosterol-d6 Suppliers
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