2-cyclopropyl-1H-imidazole
Uses- Product Name
- 2-cyclopropyl-1H-imidazole
- CAS No.
- 89532-38-7
- Chemical Name
- 2-cyclopropyl-1H-imidazole
- Synonyms
- 2-CyclopropyliMidazole;2-cyclopropyl-1H-imidazole;1H-Imidazole, 2-cyclopropyl-;2-Cyclopropyl-1H-iMidazol...
- CBNumber
- CB72512854
- Molecular Formula
- C6H8N2
- Formula Weight
- 108.14
- MOL File
- 89532-38-7.mol
2-cyclopropyl-1H-imidazole Property
- Melting point:
- 138-139℃
- Boiling point:
- 324.2±11.0 °C(Predicted)
- Density
- 1+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.39±0.10(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B424113
- Product name
- 2-Cyclopropyl-1H-imidazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 5533AJ
- Product name
- 2-Cyclopropyl-1H-imidazole
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 3H32-1-AG
- Product name
- 2-Cyclopropyl-1H-imidazole
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CHM1051897
- Product name
- 2-CYCLOPROPYL-1H-IMIDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $456.67
- Updated
- 2021/12/16
- Product number
- 3H32-1-AG
- Product name
- 2-Cyclopropyl-1H-imidazole
- Packaging
- 1g
- Price
- $575
- Updated
- 2021/12/16
2-cyclopropyl-1H-imidazole Chemical Properties,Usage,Production
Uses
2-Cyclopropyl-1H-imidazole is a heterocyclic organic compound, mainly used as a pharmaceutical intermediate.
Synthesis
131543-46-9
1489-69-6
89532-38-7
A methanol (5 mL) solution of cyclopropanecarboxaldehyde (500 mg, 7.13 mmol) and acetaldehyde (455 mg, 7.84 mmol) was added to a 25 mL round bottom flask. The reaction mixture was cooled to 0 °C, followed by dropwise addition of 25% aqueous ammonium hydroxide solution (1 mL). The resulting mixture was stirred at 0 °C for 3 h, followed by continued stirring at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was dissolved in saturated saline (50 mL). The aqueous phase was extracted with ethyl acetate (3 x 10 mL), the organic layers were combined and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the title compound 2-cyclopropyl-1H-imidazole (600 mg, 78% yield) as a light brown solid.
References
[1] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 115
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 130
[3] Patent: US2011/52578, 2011, A1
[4] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 605 - 615
2-cyclopropyl-1H-imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-cyclopropyl-1H-imidazole manufacturers
- Product
- 2-cyclopropyl-1H-imidazole 89532-38-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-09