4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid

Product Name: 4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
CAS No.: 29913-51-7
Chemical Name: 4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
Synonyms: 2-(4-Hydroxyphenyl)-2-methylpropanoicaci;4-Hydroxy-α,α-dimethylbenzeneacetic acid;4-Hydroxy-α,α-dimethyl-benzeneacetic acid;2-(4-Hydroxyphenyl)-2-Methylpropanoic acid;Benzeneacetic acid, 4-hydroxy-α,α-diMethyl-;Benzeneacetic acid, 4-hydroxy-alpha,alpha-diMethyl-;4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
CBNumber: CB72514681
Molecular Formula: C10H12O3
Formula Weight: 180.2
MOL File: 29913-51-7.mol

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4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Property

Boiling point:: 345.5±17.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.60±0.10(Predicted)

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Safety

HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H910605
Product name: 2-(4-Hydroxyphenyl)-2-methylpropanoicacid
Packaging: 5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H910605
Product name: 2-(4-Hydroxyphenyl)-2-methylpropanoicacid
Packaging: 10mg
Price: $60
Updated: 2021/12/16

TRC

Product number: H910605
Product name: 2-(4-Hydroxyphenyl)-2-methylpropanoicacid
Packaging: 50mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 6291BB
Product name: 2-(4-Hydroxyphenyl)-2-methylpropanoicacid
Packaging: 250mg
Price: $107
Updated: 2021/12/16

AK Scientific

Product number: 6291BB
Product name: 2-(4-Hydroxyphenyl)-2-methylpropanoicacid
Packaging: 100mg
Price: $82
Updated: 2021/12/16

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4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Chemical Properties,Usage,Production

Synthesis

2955-46-6

29913-51-7

Step 24c: Synthesis of 2-(4-hydroxyphenyl)-2-methylpropanoic acid (Compound 0804-27) 2-(4-Methoxyphenyl)-2-methylpropanoic acid (Compound 0803-27) (0.85 g, 4.38 mmol) was mixed with pyridine hydrochloride (2.82 g, 24.40 mmol) and the reaction was heated at 180 °C for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 6 with dilute hydrochloric acid (1 M), followed by extraction with ethyl acetate. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated to give the target product 0804-27 (0.61 g, 76% yield) as a colorless oil.LCMS detection showed m/z of 181 [M + 1]+.1H NMR (400 MHz, DMSO-d6) data were as follows: δ 1.41 (s, 6H), 6.70 (d, J = 8.8 Hz, 2H) , 7.13 (d, J = 8.8Hz, 2H), 9.28 (s, 1H), 12.16 (s, 1H).

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 26, p. 4508 - 4521
[2] Patent: WO2005/121102, 2005, A2. Location in patent: Page/Page column 25-26
[3] Patent: WO2009/36016, 2009, A1. Location in patent: Page/Page column 78c
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 17, p. 4567 - 4570
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6129 - 6152

4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Suppliers

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29913-51-7, 4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acidRelated Search:

4-hydroxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid

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29913-51-7