4-chloro-2,5-diMethoxypyriMidine

Product Name: 4-chloro-2,5-diMethoxypyriMidine
CAS No.: 370103-25-6
Chemical Name: 4-chloro-2,5-diMethoxypyriMidine
Synonyms: 2,5-DiMethoxy-4-chloropyriMidine;Pyrimidine,4-chloro-2,5-dimethoxy-
CBNumber: CB72514782
Molecular Formula: C6H7ClN2O2
Formula Weight: 174.59
MOL File: 370103-25-6.mol

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4-chloro-2,5-diMethoxypyriMidine Property

Boiling point:: 277.5±43.0℃ (760 Torr)
Density: 1.285±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 121.6±28.2℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.05±0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 4714AB
Product name: 4-Chloro-2,5-dimethoxypyrimidine
Packaging: 1g
Price: $644
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0121905
Product name: 4-CHLORO-2,5-DIMETHOXYPYRIMIDINE
Purity: 95.00%
Packaging: 10G
Price: $2772
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0121905
Product name: 4-CHLORO-2,5-DIMETHOXYPYRIMIDINE
Purity: 95.00%
Packaging: 50G
Price: $6468
Updated: 2021/12/16

Ambeed

Product number: A274480
Product name: 4-Chloro-2,5-dimethoxypyrimidine
Purity: 95+%
Packaging: 100mg
Price: $99
Updated: 2021/12/16

Ambeed

Product number: A274480
Product name: 4-Chloro-2,5-dimethoxypyrimidine
Purity: 95+%
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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4-chloro-2,5-diMethoxypyriMidine Chemical Properties,Usage,Production

Synthesis

370103-23-4

370103-25-6

General procedure for the synthesis of 2,5-dimethoxy-4-chloropyrimidine from 2,5-dimethoxy-4-hydroxypyrimidine: Example 4: 15.6 g (0.1 mol) of 2,5-dimethoxy-4-hydroxypyrimidine was suspended in 25 g of toluene. To the suspension was added 46.0 g of phosphoryl chloride and the mixture was heated to 80°C. 20.2 g of triethylamine was added slowly and dropwise over a period of 1 hour, followed by continued stirring at 80 °C for 30 minutes. Upon completion of the reaction, the mixture was poured into 600 g of ice water, stirred for 12 h, and the pH was adjusted with sodium hydroxide solution to 5. The toluene phase was separated, and the aqueous phase was extracted with toluene (50 mL each time) three times. The toluene extracts were combined and concentrated to dryness to give 12.57 g of 4-chloro-2,5-dimethoxypyrimidine as light yellow crystals with a characteristic odor. The melting point of the product was 78-80°C. Nuclear magnetic resonance hydrogen spectrum (1H-NMR) data: 3.860 ppm (s, 3H), 3.909 ppm (s, 3H), 8.446 ppm (s, 1H). Nuclear magnetic resonance carbon spectroscopy (13C-NMR) data: 55.11 ppm (OCH3), 57.42 ppm (OCH3), 143.90 ppm (C6), 145.09 ppm (C5), 149.67 ppm (C4), 158.28 ppm (C2). Gas chromatography-mass spectrometry (GC/MS) analysis showed product purity >98% with molecular ion peaks (M+) of 174/176 g/mol. yield was 72%.

References

[1] Patent: US2003/22908, 2003, A1

4-chloro-2,5-diMethoxypyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-2,5-diMethoxypyriMidine Suppliers

China 60 India 1 United States 2 Global 63

Shanghai Hanhong Scientific Co.,Ltd.

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Country: China
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Country: China
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Amber MolTech LLC

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Zhejiang Haiqiang Chemical Co.,Ltd

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View Lastest Price from 4-chloro-2,5-diMethoxypyriMidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-chloro-2,5-diMethoxypyriMidine 370103-25-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4-chloro-2,5-diMethoxypyriMidine 370103-25-6
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

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2,5-DiMethoxy-4-chloropyriMidine

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370103-25-6