1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid
- Product Name
- 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid
- CAS No.
- 1014631-89-0
- Chemical Name
- 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid
- Synonyms
- 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-(3-pyridinyl)-
- CBNumber
- CB72515512
- Molecular Formula
- C9H7N3O2
- Formula Weight
- 189.17
- MOL File
- 1014631-89-0.mol
1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to light brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P997483
- Product name
- 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylicAcid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0052801
- Product name
- 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylicacid
- Packaging
- 100mg
- Price
- $11
- Updated
- 2021/12/16
- Product number
- CS-0052801
- Product name
- 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylicacid
- Packaging
- 250mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 0389AA
- Product name
- 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylicacid
- Packaging
- 25mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-0052801
- Product name
- 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylicacid
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
77556-48-0
1014631-89-0
Stage 2: Synthesis of 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid 8.360 g (49.13 mmol) of 1-(pyridin-3-yl)-1H-pyrazole-4-carbonitrile was dissolved in 200 mL of dioxane and kept at a temperature of about 10 °C. Subsequently, 20 mL of water and 10.48 g of 45% sodium hydroxide aqueous solution were added. The reaction mixture was heated to reflux and maintained for 12 hours. Since the reaction was incomplete, 10.48 g of 45% aqueous sodium hydroxide solution was added additionally and reflux was continued for 12 hours. After completion of the reaction, the solution was cooled to room temperature and dioxane was removed by distillation under reduced pressure. The residue was diluted with a small amount of water and extracted with ethyl acetate. The aqueous phase was adjusted to pH 3 with concentrated hydrochloric acid at 0 °C. A precipitate was precipitated and collected by filtration to give 5.04 g of product. The filtrate was concentrated to half of the original volume and the precipitate was collected by filtration again to give another 2.29 g of product. The total yield was 7.33 g (72% of the theoretical yield). Product characterization: logP(HCOOH) 0.50; 1H NMR ((CD3)2SO): δ 7.55 (m, 1H), 8.08 (s, 1H), 8.28 (m, 1H), 8.57 (m, 1H), 8.98 (s, 1H), 9.13 (m, 1H).
References
[1] Patent: US2011/118290, 2011, A1. Location in patent: Page/Page column 14
1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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