4-amino-2-chloro-5-fluoropyridine
- Product Name
- 4-amino-2-chloro-5-fluoropyridine
- CAS No.
- 89510-90-7
- Chemical Name
- 4-amino-2-chloro-5-fluoropyridine
- Synonyms
- 100004;2-Chloro-5-fluoro-4-pyridinaMine;4-amino-2-chloro-5-fluoropyridine;4-PyridinaMine, 2-chloro-5-fluoro-;4-amino-2-chloro-5-fluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB72515673
- Molecular Formula
- C5H4ClFN2
- Formula Weight
- 146.55
- MOL File
- 89510-90-7.mol
4-amino-2-chloro-5-fluoropyridine Property
- Melting point:
- 110-111 °C(Solv: water (7732-18-5))
- Boiling point:
- 267.0±35.0 °C(Predicted)
- Density
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.81±0.42(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C373595
- Product name
- 2-chloro-5-fluoropyridin-4-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071066
- Product name
- 4-Amino-2-chloro-5-fluoropyridine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- PC48311
- Product name
- 4-Amino-2-chloro-5-fluoropyridine
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 071066
- Product name
- 4-Amino-2-chloro-5-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 3H30-7-Y0
- Product name
- 4-Amino-2-chloro-5-fluoropyridine
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
4-amino-2-chloro-5-fluoropyridine Chemical Properties,Usage,Production
Synthesis
405230-80-0
89510-90-7
General procedure for the synthesis of 2-chloro-5-fluoro-4-aminopyridine (12) from 2-chloro-5-fluoro-4-nitropyridine-1-oxide (11,1.3 g, 6.8 mmol): a mixture of the feedstock and 1.6 g of nickel ruanide in 80 mL of anhydrous ethanol was subjected to hydrogenation in a Parr hydrogenation unit under hydrogen pressure of 40 psi. The reaction process was monitored by thin layer chromatography (TLC) with the unfolding agent CH2Cl2/EtOAc (4:1, v/v) and the Rf values of the feedstock and the product were 0.78 and 0.71, respectively.The reaction lasted for 3 hr when the TLC showed that the feedstock disappeared and new spots were detected. After completion of the reaction, the catalyst was removed by filtration and washed carefully with ethanol. The filtrate and washings were combined and concentrated by vacuum evaporation to give 0.9 g (91% yield) of off-white solid product. A small amount of the sample was purified by recrystallization from hot water to give white crystals with a melting point of 110-111 °C. The 1H NMR (CDCl3) data of the product were as follows: δ 4.50 (br s, 2H, NH2, D2O exchangeable), 7.15 (d, 1H, 3-H, J = 6Hz), 7.95 (d, 1H, 6-H, J = 2Hz). Elemental analysis results (C5H4ClFN2) Calculated values: C, 40.97; H, 2.75; N, 19.12. Measured values: C, 41.18; H, 2.39; N, 18.89.
References
[1] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 12, p. 1975 - 2000
[2] Patent: US2004/116362, 2004, A1. Location in patent: Page/Page column 12; Figure 1
[3] Patent: WO2011/113802, 2011, A2. Location in patent: Page/Page column 107
4-amino-2-chloro-5-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-amino-2-chloro-5-fluoropyridine Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1944
- Advantage
- 55
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3989
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9520
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 020-82185713,82185709 13418171485
- Fax
- 020-82185696
- sales@chem-stone.com
- Country
- China
- ProdList
- 744
- Advantage
- 56
View Lastest Price from 4-amino-2-chloro-5-fluoropyridine manufacturers
- Product
- 4-amino-2-chloro-5-fluoropyridine 89510-90-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 4-amino-2-chloro-5-fluoropyridine 89510-90-7
- Price
- US $6.00/KG
- Min. Order
- 2KG
- Purity
- 98%
- Supply Ability
- 1KG,50KG,100KG
- Release date
- 2019-09-03