MK-3697

Product Name: MK-3697
CAS No.: 1224846-01-8
Chemical Name: MK-3697
Synonyms: CS-673;MK-3697;MK-3607;Mk3697/Mk-3697;MK-3697 , CID 46190695;MK-3697, 10 mM in DMSO;MK-3697; MK3697; MK 3697.;N-[(5,6-Dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-[2,3'-bipyridine]-4-carboxamide;N-((5,6-diMethoxypyridin-2-yl)Methyl)-5'-Methyl-5-(thiazol-2-yl)-[2,3'-bipyridine]-4-carboxaMide;[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-
CBNumber: CB72516049
Molecular Formula: C23H21N5O3S
Formula Weight: 447.51
MOL File: 1224846-01-8.mol

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MK-3697 Property

storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form: A solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3376
Product name: MK-3697
Purity: 99.46%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-3376
Product name: MK-3697
Purity: 99.46%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-3376
Product name: MK-3697
Purity: 99.46%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-3376
Product name: MK-3697
Purity: 99.46%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

AK Scientific

Product number: SYN5697
Product name: MK-3697
Packaging: 100mg
Price: $1812
Updated: 2021/12/16

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MK-3697 Chemical Properties,Usage,Production

Uses

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. IC50 value: 0.95 nM(Ki) Target: Orexin 2 receptor antagonist MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. Herein we report additional SAR studies within the “triaryl” amide 2-SORA series focused on improvements in compound stability in acidic media and time-dependent inhibition of CYP3A4. MK-3697 has improved stability and TDI profiles as well as excellent sleep efficacy across species.

References

[1] Anthony J. Roecker, et al. Discovery of MK-3697: A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia. Bioorganic & Medicinal Chemistry Letters Available online 26 August 2014

MK-3697 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-3697 Suppliers

China 67 United States 7 Global 74

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
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ProdList: 2922
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Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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ShangHai Onsyn-Chemical Technology Co., Ltd.

Tel: 021-58359326 15900795984
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shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
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CEG Chemical Science&Technology Co., Ltd.

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Country: China
ProdList: 1785
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
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LETOPHARM LIMITED

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Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
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View Lastest Price from MK-3697 manufacturers

Career Henan Chemical Co

Product: N-[(5,6-dimethoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxamide 1224846-01-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1224846-01-8, MK-3697Related Search:

N-[(5,6-Dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-[2,3'-bipyridine]-4-carboxamide

MK-3697

N-((5,6-diMethoxypyridin-2-yl)Methyl)-5'-Methyl-5-(thiazol-2-yl)-[2,3'-bipyridine]-4-carboxaMide

Mk3697/Mk-3697

MK-3607

N-[(5,6-diMethoxypyridin-2-yl)Methyl]-5'-Methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxaMide

N-[(5,6-DIMETHOXYPYRIDIN-2-YL)METHYL]-2-(5-METHYLPYRIDIN-3-YL)-5-(1,3-THIAZOL-2-YL)PYRIDINE-4-CARBOXAMIDE

MK-3697 , CID 46190695

CS-673

MK-3697; MK3697; MK 3697.

[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-

Inhibitor,Hypocretin Receptor,MK3697,MK 3697,inhibit,Orexin Receptor (OX Receptor),HCRT Receptor,MK-3697

N-[(5,6-dimethoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-[2,3'-bipyridine]-4-carboxamide

MK-3697, 10 mM in DMSO

1224846-01-8

Inhibitors