N-Acetylpiperidine-4-acetic acid
- Product Name
- N-Acetylpiperidine-4-acetic acid
- CAS No.
- 78056-60-7
- Chemical Name
- N-Acetylpiperidine-4-acetic acid
- Synonyms
- 1-Acetyl-4-piperidineacetic acid;N-Acetylpiperidine-4-acetic acid;4-Piperidineacetic acid, 1-acetyl-;(N-Acetylpiperidin-4-yl)acetic acid
- CBNumber
- CB72516236
- Molecular Formula
- C9H15NO3
- Formula Weight
- 185.22
- MOL File
- 78056-60-7.mol
N-Acetylpiperidine-4-acetic acid Property
- Density
- 1.150
- storage temp.
- Store at room temperature
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A192813
- Product name
- 1-Acetyl-4-piperidineaceticacid
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W8434
- Product name
- 1-Acetyl-4-piperidineaceticacid
- Packaging
- 5g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- CHM0080377
- Product name
- (1-ACETYLPIPERIDIN-4-YL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $726
- Updated
- 2021/12/16
- Product number
- CHM0080377
- Product name
- (1-ACETYLPIPERIDIN-4-YL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.5
- Updated
- 2021/12/16
- Product number
- CHM0080377
- Product name
- (1-ACETYLPIPERIDIN-4-YL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1443.75
- Updated
- 2021/12/16
N-Acetylpiperidine-4-acetic acid Chemical Properties,Usage,Production
Synthesis
78056-59-4
78056-60-7
General procedure for the synthesis of N-acetylpiperidine-4-acetic acid from ethyl 1-acetyl-4-piperidineacetate (CAS: 78056-59-4): to a stirred solution of 92 parts of ethyl 1-acetyl-4-piperidineacetate in 200 parts of ethanol was slowly added 60 parts of a 30% sodium hydroxide solution dropwise. After the addition was completed, the reaction mixture was continued to be stirred in a warm water bath for 2 hours. Subsequently, the reaction mixture was poured into water and the entire mixture was filtered using a hyflo filter aid. The clarified filtrate was concentrated to one-third of the original volume and then the concentrate was acidified with dilute hydrochloric acid solution. The product was crystallized under cooling conditions. Finally, the crystallized product was filtered and dried to give 29 parts (36.5% yield) of 1-acetyl-4-piperidineacetic acid with a melting point of 124.1 °C.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 25, p. 5512 - 5532
[2] Patent: US4254127, 1981, A
N-Acetylpiperidine-4-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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