Benzoic acid, 2-amino-3-bromo-, methyl ester
- Product Name
- Benzoic acid, 2-amino-3-bromo-, methyl ester
- CAS No.
- 104670-74-8
- Chemical Name
- Benzoic acid, 2-amino-3-bromo-, methyl ester
- Synonyms
- Methyl 2-aMino-3-broMobenzoate;2-amino-3-bromo-;Ethyl 3-bromo-2-aminobenzoate;2-Amino-3-Bromo-, Methyl Ester;3-Bromoanthranilic acid methyl ester;Benzoic acid, 2-amino-3-bromo-, methyl ester
- CBNumber
- CB72518119
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 104670-74-8.mol
Benzoic acid, 2-amino-3-bromo-, methyl ester Property
- Melting point:
- 47-48℃
- Boiling point:
- 287.2±20.0 °C(Predicted)
- Density
- 1.578±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 0.13±0.10(Predicted)
- color
- Light brown
- InChI
- InChI=1S/C8H8BrNO2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,10H2,1H3
- InChIKey
- FGSIUBWPZRBMOC-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(Br)=C1N
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M328418
- Product name
- Methyl2-amino-3-bromobenzoate
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 454780
- Product name
- Methyl 2-amino-3-bromobenzoate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 075843
- Product name
- Methyl 2-amino-3-bromobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-W018624
- Product name
- Methyl2-amino-3-bromobenzoate
- Purity
- 99.72%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-W018624
- Product name
- Methyl2-amino-3-bromobenzoate
- Purity
- 99.72%
- Packaging
- 10g
- Price
- $96
- Updated
- 2021/12/16
Benzoic acid, 2-amino-3-bromo-, methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
20776-51-6
104670-74-8
Example 1: Synthesis of 3-(3-methylaminosulfonyl-phenylethynyl)-2-pyrrol-1-yl-benzoic acid 2-amino-3-bromo-benzoic acid methyl ester: 2-amino-3-bromo-benzoic acid (5 g, 23 mmol) was dissolved in methanol (30 mL) and concentrated sulfuric acid (1 mL) was added slowly and dropwise. The reaction mixture was refluxed at 80 °C for 24 h and subsequently cooled to room temperature. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was diluted with distilled water (10 mL) and the pH was adjusted to alkaline with saturated sodium bicarbonate solution. Extraction was performed using ethyl acetate (20 mL x 3) and the organic layers were combined. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated. Purification was carried out by silica gel column chromatography (80 g) with ethyl acetate/hexane (10%) as eluent to give the colorless oily product methyl 2-amino-3-bromo-benzoate (5 g, 95% yield).
References
[1] Patent: WO2015/73864, 2015, A1. Location in patent: Paragraph 0253-0254; 0413
[2] Patent: WO2011/25859, 2011, A1. Location in patent: Page/Page column 59
[3] Patent: US2011/71136, 2011, A1. Location in patent: Page/Page column 31
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2781 - 2787
[5] Patent: US2009/239859, 2009, A1. Location in patent: Page/Page column 298
Benzoic acid, 2-amino-3-bromo-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzoic acid, 2-amino-3-bromo-, methyl ester manufacturers
- Product
- methyl 2-amino-3-bromobenzoate 104670-74-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-20
- Product
- Benzoic acid, 2-amino-3-bromo-, methyl ester 104670-74-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30