Biphenylindanone A

Product Name: Biphenylindanone A
CAS No.: 866823-73-6
Chemical Name: Biphenylindanone A
Synonyms: BINA;CS-203;MRLSD 230;BINA, >=98%;Biphenylindanone A;4-[3-[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydroinden-5-yl)oxymethyl]phenyl]benzoic acid;3'-[[(2-Cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl]biphenyl-4-carboxylic acid;3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylicacid;[1,1'-Biphenyl]-4-carboxylic acid, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-diMethyl-1-oxo-1H-inden-5-yl)oxy]Methyl]-
CBNumber: CB72518270
Molecular Formula: C30H30O4
Formula Weight: 454.56
MOL File: 866823-73-6.mol

More

Less

Biphenylindanone A Property

Melting point:: 238-241℃
Boiling point:: 676.9±55.0 °C(Predicted)
Density: 1.220
storage temp.: Desiccate at RT
solubility: DMSO: ≥18mg/mL
pka: 4.17±0.10(Predicted)
form: powder
color: white to tan

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04463
Product name: BINA - CAS 866823-73-6 - Calbiochem
Packaging: 5mg
Price: $257
Updated: 2023/01/07

Sigma-Aldrich

Product number: B8688
Product name: Biphenyl-indanone A
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $181
Updated: 2022/05/15

Sigma-Aldrich

Product number: B8688
Product name: Biphenyl-indanone A
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $694
Updated: 2022/05/15

Cayman Chemical

Product number: 11986
Product name: Biphenylindanone A
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 11986
Product name: Biphenylindanone A
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

More

Less

Biphenylindanone A Chemical Properties,Usage,Production

Description

The metabotropic glutamate receptor 2 (mGluR2) is a G_i/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC₅₀ values of 33.2 and 96 nM, respectively. It has no effect on glutamate-induced activation of other mGluR types. BINA can be used on cells, tissues, or animals. Because of its selectivity for mGluR2, robust in vivo activity, and brain penetrance, BINA can be used to elucidate the role of mGluR2 in such diverse processes as psychosis, schizophrenia, and drug addiction.

Uses

Biphenylindanone A is an orally active metabotropic glutamate subtype 2 receptor positive allosteric modulator.

Definition

ChEBI: Biphenylindanone a is a member of biphenyls.

IC 50

mGluR2

storage

Room temperature (desiccate)

References

[1] RUGGERO GALICI. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 318 1: 173-185. DOI: 10.1124/jpet.106.102046
[2] RAVEENDRA-PANICKAR DHANYA. Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats[J]. Journal of Medicinal Chemistry, 2010, 54 1: 342-353. DOI: 10.1021/jm1012165
[3] MICHAEL A BENNEYWORTH. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.[J]. Molecular Pharmacology, 2007, 72 2: 477-484. DOI: 10.1124/mol.107.035170
[4] E.A. HACKLER . Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation[J]. Neuroscience, 2010, 168 1: Pages 209-218. DOI: 10.1016/j.neuroscience.2010.02.057
[5] XINCHUN JIN. The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats[J]. Neuropsychopharmacology, 2010, 35 10: 2021-2036. DOI: 10.1038/npp.2010.82

Biphenylindanone A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Biphenylindanone A Suppliers

Canada 1 China 50 India 1 United Kingdom 1 United States 12 Global 65

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: zwchem@163.com
Country: China
ProdList: 617
Advantage: 61

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

More

Less

View Lastest Price from Biphenylindanone A manufacturers

Career Henan Chemical Co

Product: Biphenylindanone A 866823-73-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

866823-73-6, Biphenylindanone ARelated Search:

Biphenylindanone A

3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylicacid

BINA

3'-[[(2-Cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl]biphenyl-4-carboxylic acid

MRLSD 230

4-[3-[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydroinden-5-yl)oxymethyl]phenyl]benzoic acid

CS-203

[1,1'-Biphenyl]-4-carboxylic acid, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-diMethyl-1-oxo-1H-inden-5-yl)oxy]Methyl]-

BINA, >=98%

866823-73-6

C30H30O4