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BIO 1211

Product Name
BIO 1211
CAS No.
187735-94-0
Chemical Name
BIO 1211
Synonyms
BIO 1211;inhibit,BIO1211,BIO-1211,Integrin,BIO 1211,Inhibitor;L-Proline, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-;(2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylicacid
CBNumber
CB72518836
Molecular Formula
C36H48N6O9
Formula Weight
708.81
MOL File
187735-94-0.mol
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BIO 1211 Property

Boiling point:
962.2±65.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 2 mg/ml in 0.2M PBS
form 
solid
pka
3.40±0.20(Predicted)
color 
White
Water Solubility 
Soluble to 2 mg/ml in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
3910
Product name
BIO1211
Packaging
1
Price
$184
Updated
2021/12/16
Usbiological
Product number
254769
Product name
BIO 1211
Packaging
1mg
Price
$423
Updated
2021/12/16
TRC
Product number
B591710
Product name
BIO1211
Packaging
5mg
Price
$730
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001074
Product name
BIO-1211
Purity
95.00%
Packaging
5MG
Price
$786.45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001074
Product name
BIO-1211
Purity
95.00%
Packaging
1MG
Price
$697.34
Updated
2021/12/16
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BIO 1211 Chemical Properties,Usage,Production

Uses

BIO 1211 is a selective, high affinity α4β1 (VLA-4) inhibitor.

Biological Activity

BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurk at surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease models in vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.).

in vivo

BIO-1211 (5 and 10 mg/kg, orally, once every other day) results in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in EAE in a dose-independent manner. BIO-1211 exhibits a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex[2].

Animal Model:Naive, C57BL/6 mice (male, 8 weeks old, 20-25 g weight)[2].
Dosage:5 and 10 mg/kg.
Administration:Orally once every other day starting the day before immunization until day 21 post-immunization.
Result:Could prevent the induction of EAE.
Significantly delayed the onset of EAE and reduced the severity of clinical EAE compared to the vehicle group.
Markedly reduced the expression of both CD11b and CD45 in comparison with the vehicle group.
mRNA and soluble form of a subset of target inflammatory cytokines (IFNγ, IL-17, and TNF-α) was dramatically decreased.

IC 50

α4β1: 4 nM (IC50); α4β7: 2 μM (IC50)

storage

Store at -20°C

BIO 1211 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIO 1211 Suppliers

China 45 United Kingdom 1 United States 7 Global 53
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29763
Advantage
68
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7062
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
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187735-94-0, BIO 1211Related Search:


  • BIO 1211
  • L-Proline, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-
  • (2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carboxylicacid
  • inhibit,BIO1211,BIO-1211,Integrin,BIO 1211,Inhibitor
  • 187735-94-0
  • C36H48N6O9