ChemicalBook > CAS DataBase List > 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid

3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid

Product Name
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid
CAS No.
196961-43-0
Chemical Name
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid
Synonyms
CD 3254;CD3254,CD-3254;CD3254, 10 mM in DMSO;3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid;2-Propenoic acid, 3-[4-hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-
CBNumber
CB72518841
Molecular Formula
C24H28O3
Formula Weight
364.48
MOL File
196961-43-0.mol
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3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Property

Melting point:
165 - 167°C
Boiling point:
508.0±50.0 °C(Predicted)
Density 
1.108±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.61±0.10(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20870
Product name
CD3254
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
20870
Product name
CD3254
Purity
≥98%
Packaging
5mg
Price
$123
Updated
2024/03/01
Cayman Chemical
Product number
20870
Product name
CD3254
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
Tocris
Product number
3302
Product name
CD3254
Purity
≥97%(HPLC)
Packaging
10
Price
$233
Updated
2021/12/16
Tocris
Product number
3302
Product name
CD3254
Purity
≥97%(HPLC)
Packaging
50
Price
$952
Updated
2021/12/16
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3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Chemical Properties,Usage,Production

Description

CD3254 is a selective agonist of the retinoid X receptors (RXRs; EC50 = ~10 nM for human RXRβ) that is without effect on retinoic acid receptors (RARs). It stimulates the recruitment of the nuclear receptor interaction domain of the TRAP220 coactivator to RXRα/RARβ heterodimers in vitro. CD3254 also enhances the recruitment of the PPARγ coactivator 1α, PGC-1α, to RXRα/PPARγ heterodimers.

Uses

CD 3254 is a potent RXR agonist.

storage

Store at -20°C

References

[1] VIRGINIE NAHOUM. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 44: 17323-17328. DOI: 10.1073/pnas.0705356104
[2] PETER W. JURUTKA. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)[J]. Journal of Medicinal Chemistry, 2013, 56 21: 8432-8454. DOI: 10.1021/jm4008517
[3] VIVIAN POGENBERG. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.[J]. The Journal of Biological Chemistry, 2005, 280 2: 1625-1633. DOI: 10.1074/jbc.m409302200
[4] ALBANE LE MAIRE. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.[J]. EMBO Reports, 2009, 10 4: 367-373. DOI: 10.1038/embor.2009.8

3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Suppliers

China 44 United Kingdom 1 United States 9 Global 54
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
3011
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
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58

196961-43-0, 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacidRelated Search:

Hydroxyurea L-Hydroxyproline CHLOROPHOSPHONAZO III

  • 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid
  • CD 3254
  • 2-Propenoic acid, 3-[4-hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-
  • CD3254,CD-3254
  • CD3254, 10 mM in DMSO
  • 196961-43-0