MMK 1
- Product Name
- MMK 1
- CAS No.
- 271246-66-3
- Chemical Name
- MMK 1
- Synonyms
- MMK 1;MMK-1 trifluoroacetate;L-Methionine, L-leucyl-L-α-glutamyl-L-seryl-L-isoleucyl-L-phenylalanyl-L-arginyl-L-seryl-L-leucyl-L-leucyl-L-phenylalanyl-L-arginyl-L-valyl-
- CBNumber
- CB72518861
- Molecular Formula
- C75H123N19O18S
- Formula Weight
- 1610.96
- MOL File
- 271246-66-3.mol
MMK 1 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 0.50 mg/ml in 25% ethanol / water with sonication
- form
- film or powder
- color
- white to beige
- Water Solubility
- Soluble to 1 mg/ml in 25% ethanol / Water
- Sequence
- H-Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met-OH
N-Bromosuccinimide Price
- Product number
- SML3075
- Product name
- MMK-1 trifluoroacetate
- Purity
- ≥95% (HPLC)
- Packaging
- 1 mg
- Price
- $130.15
- Updated
- 2025/07/31
- Product number
- 3537
- Product name
- MMK1
- Packaging
- 1
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 255880
- Product name
- MMK 1
- Packaging
- 1mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- B5446
- Product name
- MMK1
- Packaging
- 1mg
- Price
- $219
- Updated
- 2021/12/16
- Product number
- PEP0004511
- Product name
- MMK 1
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.08
- Updated
- 2021/12/16
MMK 1 Chemical Properties,Usage,Production
Uses
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4].
Biological Activity
MMK-1 is a potent and selective FPR2 (FPRL-1) agonist (Ca2+ flux EC50 <2 nM/FPR2 vs. >10 μM/FPR1 with respective HEK293 transfectants) and an effective calcium-mobilizing and chemotactic agent for human monocytes & neutrophils (1-1000 nM). MMK-1 increases pertussis toxin-sensitive inflammatory cytokines production in human monocyte cultures (50 ng/mL PT & 10 μM MMK-1), exerts anxiolytic-like activities in mice (100 pmol/mouse icv) and shows anti-alopecia efficacy in rats in vivo (100 mg/kg p.o. or 10 mg/kg i.p.).
in vivo
MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4].
| Animal Model: | Four-week-old male ddY mice[4] |
| Dosage: | 10, 100, 1000 pmol/mouse |
| Administration: | ICV; 20 min before the test |
| Result: | Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse. |
IC 50
Calcium Channel
storage
Store at -20°C
References
[1] C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. DOI:10.1038/4310
[2] Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. DOI:10.3390/cells10081975
[3] Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. DOI:10.1038/s41598-018-32963-5
[4] Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. DOI:10.1016/j.peptides.2016.07.001
MMK 1 Preparation Products And Raw materials
Raw materials
Preparation Products
MMK 1 Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29760
- Advantage
- 68
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 15397062932
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2923
- Advantage
- 58
- Tel
- 0571-0571-88211921 19105816207
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58