7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride

Product Name: 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
CAS No.: 371980-98-2
Chemical Name: 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
Synonyms: SB 612111;SB612111,SB 612111;SB 612111 hydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol;(5S,7S)-7-((4-(2,6-DICHLOROPHENYL)PIPERIDIN-1-YL)METHYL)-1-METHYL-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL HCL;5H-Benzocyclohepten-5-ol, 7-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-, (5S,7S)-;7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]Methyl]-6,7,8,9-tetrahydro-1-Methyl-5H-benzocyclohepten-5-ol Hydrochloride;(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]Methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Hydrochloride
CBNumber: CB72518896
Molecular Formula: C24H29Cl2NO
Formula Weight: 418.4
MOL File: 371980-98-2.mol

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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Property

Boiling point:: 530.9±50.0 °C(Predicted)
Density: 1.207
storage temp.: Store at -20°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: 14.68±0.40(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0571
Product name: SB-612111 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0571
Product name: SB-612111 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $531
Updated: 2024/03/01

Tocris

Product number: 3573
Product name: SB-612111 hydrochloride
Purity: ≥97%(HPLC)
Packaging: 10
Price: $267
Updated: 2021/12/16

Tocris

Product number: 3573
Product name: SB-612111 hydrochloride
Purity: ≥97%(HPLC)
Packaging: 50
Price: $1122
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BIO0000215
Product name: SB-612111 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $1963.5
Updated: 2021/12/16

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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Chemical Properties,Usage,Production

Uses

A selective nociceptin/orphanin FQ receptor antagonist. A potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response.

Uses

A selective nociceptin/orphanin FQ receptor antagonist, 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride can act as a potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response.

Biochem/physiol Actions

SB-612111 is a potent antagonist of the nociceptin receptor ORL-1. SB-612111 binds to ORL-1 with high affinity (Ki = 0.33 nM) but has very low affinity for classic opioid receptors. The compound SB-612111 antagonizes the anti-morphine effects of nociceptin and blocks nociceptin-induced thermal hyperalgesia.

7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Preparation Products And Raw materials

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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Suppliers

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371980-98-2, 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochlorideRelated Search:

7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride

SB 612111 hydrochloride

SB 612111

(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]Methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Hydrochloride

(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]Methyl]-6,7,8,9-tetrahydro-1-Methyl-5H-benzocyclohepten-5-ol Hydrochloride

(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol

(5S,7S)-7-((4-(2,6-DICHLOROPHENYL)PIPERIDIN-1-YL)METHYL)-1-METHYL-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL HCL

5H-Benzocyclohepten-5-ol, 7-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-, (5S,7S)-

SB612111,SB 612111

371980-98-2

C24H29Cl2NO

C24H30Cl3NO

C24H29Cl2NOHCl

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