ChemicalBook > CAS DataBase List > 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
- Product Name
- 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
- CAS No.
- 371980-98-2
- Chemical Name
- 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride
- Synonyms
- SB 612111;SB612111,SB 612111;SB 612111 hydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol;(5S,7S)-7-((4-(2,6-DICHLOROPHENYL)PIPERIDIN-1-YL)METHYL)-1-METHYL-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL HCL;5H-Benzocyclohepten-5-ol, 7-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-, (5S,7S)-;7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]Methyl]-6,7,8,9-tetrahydro-1-Methyl-5H-benzocyclohepten-5-ol Hydrochloride;(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]Methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Hydrochloride
- CBNumber
- CB72518896
- Molecular Formula
- C24H29Cl2NO
- Formula Weight
- 418.4
- MOL File
- 371980-98-2.mol
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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Property
- Boiling point:
- 530.9±50.0 °C(Predicted)
- Density
- 1.207
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 14.68±0.40(Predicted)
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0571
- Product name
- SB-612111 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0571
- Product name
- SB-612111 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $531
- Updated
- 2024/03/01
Tocris
- Product number
- 3573
- Product name
- SB-612111 hydrochloride
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $267
- Updated
- 2021/12/16
Tocris
- Product number
- 3573
- Product name
- SB-612111 hydrochloride
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $1122
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- BIO0000215
- Product name
- SB-612111 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1963.5
- Updated
- 2021/12/16
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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Chemical Properties,Usage,Production
Uses
A selective nociceptin/orphanin FQ receptor antagonist. A potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response.
Uses
A selective nociceptin/orphanin FQ receptor antagonist, 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride can act as a potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response.
Biochem/physiol Actions
SB-612111 is a potent antagonist of the nociceptin receptor ORL-1. SB-612111 binds to ORL-1 with high affinity (Ki = 0.33 nM) but has very low affinity for classic opioid receptors. The compound SB-612111 antagonizes the anti-morphine effects of nociceptin and blocks nociceptin-induced thermal hyperalgesia.
7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77