3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Product Name: 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CAS No.: 412960-54-4
Chemical Name: 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Synonyms: Eeyarestatin 1;Eeyarestatin I;Eeyarestatin I - CAS 412960-54-4 - Calbiochem;Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1;3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea;3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide;1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CBNumber: CB72518902
Molecular Formula: C27H25Cl2N7O7
Formula Weight: 630
MOL File: 412960-54-4.mol

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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL
form: Light yellow-orange solid
pka: 9.13±0.40(Predicted)
color: Yellow to orange

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E1286
Product name: Eeyarestatin I
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $324
Updated: 2024/03/01

Sigma-Aldrich

Product number: 324521
Product name: Eeyarestatin I
Packaging: 25mg
Price: $251
Updated: 2024/03/01

Cayman Chemical

Product number: 10012609
Product name: Eeyarestatin 1
Purity: ≥98%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 10012609
Product name: Eeyarestatin 1
Purity: ≥98%
Packaging: 10mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 10012609
Product name: Eeyarestatin 1
Purity: ≥98%
Packaging: 25mg
Price: $201
Updated: 2024/03/01

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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Chemical Properties,Usage,Production

Uses

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation.

Biochem/physiol Actions

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.

storage

Store at +4°C

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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412960-54-4, 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazideRelated Search:

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Eeyarestatin I

Eeyarestatin 1

Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1

Eeyarestatin I - CAS 412960-54-4 - Calbiochem

1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea

412960-54-4

C27H25Cl2N7O7