ChemicalBook > CAS DataBase List > 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
- Product Name
- 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
- CAS No.
- 768404-03-1
- Chemical Name
- 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
- Synonyms
- 5-BDBD;5-BDBD, 10 mM in DMSO;5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one;5-(3-bromophenyl)-1,3-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one;2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, 5-(3-bromophenyl)-1,3-dihydro-;inhibit,P2X Receptor,5-BDBD,P2XRs,currents,NTG,hyperalgesia,selective,Inhibitor,ATP,5BDBD,acute,5 BDBD
- CBNumber
- CB72518942
- Molecular Formula
- C17H11BrN2O2
- Formula Weight
- 355.19
- MOL File
- 768404-03-1.mol
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5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL (clear solution)
- form
- powder
- color
- white to beige
- InChI
- InChI=1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
- InChIKey
- NKYMVQPXXTZHSF-UHFFFAOYSA-N
- SMILES
- N1=C(C2=CC=CC(Br)=C2)C2OC3=CC=CC=C3C=2NC(=O)C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0450
- Product name
- 5-BDBD
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118.75
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML0450
- Product name
- 5-BDBD
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $353.5
- Updated
- 2025/07/31
Tocris
- Product number
- 3579
- Product name
- 5-BDBD
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $197
- Updated
- 2021/12/16
Tocris
- Product number
- 3579
- Product name
- 5-BDBD
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $847
- Updated
- 2021/12/16
TRC
- Product number
- B129503
- Product name
- 5-BDBD
- Packaging
- 25mg
- Price
- $1320
- Updated
- 2021/12/16
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5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Chemical Properties,Usage,Production
Uses
5-BDBD is a potent P2X4 receptor antagonist.
Biochem/physiol Actions
5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC50 of 500 nM.
in vivo
5-BDBD (28 mg/kg; i.p.; daily for 9 days) can completely blocke the basal hyperalgesia induced by recurrent NTG injection[2].
| Animal Model: | Male C57BL/6 mice[2] |
| Dosage: | 28 mg/kg |
| Administration: | I.p.; daily for 9 days |
| Result: | Prevented NTG-induced mechanical hypersensitivity. |
IC 50
P2X4 Receptor
storage
Store at RT
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77