ChemicalBook > CAS DataBase List > 6-Quinazolinol, 4-chloro-7-methoxy-
6-Quinazolinol, 4-chloro-7-methoxy-
- Product Name
- 6-Quinazolinol, 4-chloro-7-methoxy-
- CAS No.
- 574745-97-4
- Chemical Name
- 6-Quinazolinol, 4-chloro-7-methoxy-
- Synonyms
- 4-chloro-7-Methoxyquinazolin-6-ol;4-Chloro-6-hydroxy-7-Methoxyquinazoline;4-Chloro-6-hydroxy-7-meth...;6-Quinazolinol, 4-chloro-7-methoxy-
- CBNumber
- CB72525232
- Molecular Formula
- C9H7ClN2O2
- Formula Weight
- 210.62
- MOL File
- 574745-97-4.mol
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6-Quinazolinol, 4-chloro-7-methoxy- Property
- Boiling point:
- 355.8±37.0 °C(Predicted)
- Density
- 1.458±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.55±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C377283
- Product name
- 4-chloro-7-methoxyquinazolin-6-ol
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068427
- Product name
- 4-Chloro-6-hydroxy-7-methoxyquinazoline
- Purity
- >95%
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068427
- Product name
- 4-Chloro-6-hydroxy-7-methoxyquinazoline
- Purity
- >95%
- Packaging
- 250mg
- Price
- $106
- Updated
- 2021/12/16
AK Scientific
- Product number
- 5900AE
- Product name
- 4-Chloro-6-hydroxy-7-methoxyquinazoline
- Packaging
- 100mg
- Price
- $121
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068427
- Product name
- 4-Chloro-6-hydroxy-7-methoxyquinazoline
- Purity
- >95%
- Packaging
- 500mg
- Price
- $163
- Updated
- 2021/12/16
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6-Quinazolinol, 4-chloro-7-methoxy- Chemical Properties,Usage,Production
Synthesis
230955-75-6
574745-97-4
General procedure for the synthesis of 4-chloro-7-methoxy-6-ol from 6-acetoxy-4-chloro-7-methoxyquinazoline: 4-chloro-7-methoxyquinazolin-6-yl acetate (prepared according to the method described in Example 25-5 of WO01/66099, 10.1 g, 40 mmol) was suspended in 6 N methanol-ammonia solution (200 mL) and stirred at room temperature for 90 minutes at room temperature. Upon completion of the reaction, the solvent was removed by evaporation under vacuum. Water was added to the residue and the resulting suspension was filtered. The collected solids were washed sequentially with water and ether and subsequently dried at high temperature. Finally, vacuum drying in the presence of phosphorus pentoxide gave 4-chloro-7-methoxyquinazolin-6-ol (7.9 g, 94% yield). The NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 4.02 (s, 3H), 7.40 (s, 1H), 7.43 (s, 1H), 8.81 (s, 1H).
References
[1] Patent: WO2005/26151, 2005, A1. Location in patent: Page/Page column 124
[2] European Journal of Medicinal Chemistry, 2018, vol. 147, p. 130 - 149
[3] Patent: CN106986895, 2017, A. Location in patent: Paragraph 0072; 0073; 0074; 0075; 0076
[4] Patent: CN105384699, 2016, A. Location in patent: Paragraph 0032; 0033
[5] Patent: CN105418517, 2016, A. Location in patent: Paragraph 0026; 0030; 0031
6-Quinazolinol, 4-chloro-7-methoxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Quinazolinol, 4-chloro-7-methoxy- manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 4-chloro-7-methoxyquinazolin-6-ol 574745-97-4
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17