3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
- Product Name
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
- CAS No.
- 107818-55-3
- Chemical Name
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
- Synonyms
- methyl 3-amino-5-bromothiophene-2-carboxylate;Methyl 3-amino-5-bromo-2-thiophenecarboxylate;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl este;3-Amino-5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-3-aminothiophene-2-carboxylic acid methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-5-bromo-, methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester ISO 9001：2015 REACH
- CBNumber
- CB72525883
- Molecular Formula
- C6H6BrNO2S
- Formula Weight
- 236.09
- MOL File
- 107818-55-3.mol
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Property
- Boiling point:
- 345.5±37.0 °C(Predicted)
- Density
- 1.745±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.00±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H6BrNO2S/c1-10-6(9)5-3(8)2-4(7)11-5/h2H,8H2,1H3
- InChIKey
- RZYLOBBUEWSONL-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)SC(Br)=CC=1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M332783
- Product name
- Methyl3-Amino-5-bromothiophene-2-carboxylate
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- P000592667
- Product name
- Methyl 3-amino-5-bromothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- P000592667
- Product name
- Methyl 3-amino-5-bromothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- P000592667
- Product name
- Methyl 3-amino-5-bromothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 071101
- Product name
- Methyl 3-amino-5-bromothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
22288-78-4
107818-55-3
The general procedure for the synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate from methyl 3-amino-2-thiophenecarboxylate is as follows: Example 1: Synthesis of N-(3-aminopropyl)-N-[1-(3-benzyl-6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-2-(dimethylamino)-2-oxoethyl]-4-methylbenzamide (Compound 5 in Table 1) Step 1. Synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate Methyl 3-amino-2-thiophenecarboxylate (1 eq., 25 g) was dissolved in a mixed solvent of 250 ml of dichloromethane and 250 ml of methanol, phenyltrimethylammonium tribromide (3 eq., 180 g) was added followed by calcium carbonate (in appropriate amount). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the calcium carbonate was removed by filtration and the filtrate was concentrated under reduced pressure. To the concentrated filtrate was added water (750 ml) and then extracted with ethyl acetate (1 L). The ethyl acetate layer was washed sequentially with water, sodium thiosulfate solution, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic layer was dried with magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast chromatography to afford 21.46 g (57% yield) of methyl 3-amino-5-bromothiophene-2-carboxylate as a light brown oil, the mass spectrum showed MH+ = 238.1.
References
[1] Patent: KR101736387, 2017, B1. Location in patent: Paragraph 0208-0210
[2] Patent: WO2004/111058, 2004, A1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2535 - 2539
[4] Patent: WO2005/95386, 2005, A1. Location in patent: Page/Page column 110
[5] Patent: EP2540728, 2013, A1
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester manufacturers
- Product
- Methyl 3-amino-5-bromothiophene-2-carboxylate 107818-55-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester 107818-55-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 827
- Release date
- 2019-09-02