3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester

Product Name: 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
CAS No.: 107818-55-3
Chemical Name: 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
Synonyms: methyl 3-amino-5-bromothiophene-2-carboxylate;Methyl 3-amino-5-bromo-2-thiophenecarboxylate;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl este;3-Amino-5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-3-aminothiophene-2-carboxylic acid methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-5-bromo-, methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester ISO 9001：2015 REACH
CBNumber: CB72525883
Molecular Formula: C6H6BrNO2S
Formula Weight: 236.09
MOL File: 107818-55-3.mol

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3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Property

Boiling point:: 345.5±37.0 °C(Predicted)
Density: 1.745±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.00±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C6H6BrNO2S/c1-10-6(9)5-3(8)2-4(7)11-5/h2H,8H2,1H3
InChIKey: RZYLOBBUEWSONL-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)SC(Br)=CC=1N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332783
Product name: Methyl3-Amino-5-bromothiophene-2-carboxylate
Packaging: 500mg
Price: $265
Updated: 2021/12/16

Ark Pharm

Product number: P000592667
Product name: Methyl 3-amino-5-bromothiophene-2-carboxylate
Purity: 97%
Packaging: 100mg
Price: $27
Updated: 2021/12/16

Ark Pharm

Product number: P000592667
Product name: Methyl 3-amino-5-bromothiophene-2-carboxylate
Purity: 97%
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Ark Pharm

Product number: P000592667
Product name: Methyl 3-amino-5-bromothiophene-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 071101
Product name: Methyl 3-amino-5-bromothiophene-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $285
Updated: 2021/12/16

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3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

22288-78-4

107818-55-3

The general procedure for the synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate from methyl 3-amino-2-thiophenecarboxylate is as follows: Example 1: Synthesis of N-(3-aminopropyl)-N-[1-(3-benzyl-6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-2-(dimethylamino)-2-oxoethyl]-4-methylbenzamide (Compound 5 in Table 1) Step 1. Synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate Methyl 3-amino-2-thiophenecarboxylate (1 eq., 25 g) was dissolved in a mixed solvent of 250 ml of dichloromethane and 250 ml of methanol, phenyltrimethylammonium tribromide (3 eq., 180 g) was added followed by calcium carbonate (in appropriate amount). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the calcium carbonate was removed by filtration and the filtrate was concentrated under reduced pressure. To the concentrated filtrate was added water (750 ml) and then extracted with ethyl acetate (1 L). The ethyl acetate layer was washed sequentially with water, sodium thiosulfate solution, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic layer was dried with magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast chromatography to afford 21.46 g (57% yield) of methyl 3-amino-5-bromothiophene-2-carboxylate as a light brown oil, the mass spectrum showed MH+ = 238.1.

References

[1] Patent: KR101736387, 2017, B1. Location in patent: Paragraph 0208-0210
[2] Patent: WO2004/111058, 2004, A1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2535 - 2539
[4] Patent: WO2005/95386, 2005, A1. Location in patent: Page/Page column 110
[5] Patent: EP2540728, 2013, A1

3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Suppliers

China 84 India 3 United States 10 Global 97

Accela ChemBio Inc.

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Matrix Scientific

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View Lastest Price from 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 3-amino-5-bromothiophene-2-carboxylate 107818-55-3
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester 107818-55-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 827
Release date: 2019-09-02

107818-55-3, 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl esterRelated Search:

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107818-55-3