6-(Methylsulfonyl)-3-pyridinamine
- Product Name
- 6-(Methylsulfonyl)-3-pyridinamine
- CAS No.
- 187143-22-2
- Chemical Name
- 6-(Methylsulfonyl)-3-pyridinamine
- Synonyms
- 6-(Methylsulfonyl)-3-pyridinamine;3-Pyridinamine, 6-(methylsulfonyl)-
- CBNumber
- CB72527690
- Molecular Formula
- C6H8N2O2S
- Formula Weight
- 172.2
- MOL File
- 187143-22-2.mol
6-(Methylsulfonyl)-3-pyridinamine Property
- Melting point:
- 171-173 °C
- Boiling point:
- 454.2±45.0 °C(Predicted)
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -0.67±0.10(Predicted)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M260140
- Product name
- 6-Methanesulfonylpyridin-3-amine
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M260140
- Product name
- 6-Methanesulfonylpyridin-3-amine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 6291AD
- Product name
- 6-(Methylsulfonyl)-3-pyridinamine
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 054910
- Product name
- 6-(Methylsulfonyl)-3-pyridinamine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 054910
- Product name
- 6-(Methylsulfonyl)-3-pyridinamine
- Purity
- >95%
- Packaging
- 1g
- Price
- $380
- Updated
- 2021/12/16
6-(Methylsulfonyl)-3-pyridinamine Chemical Properties,Usage,Production
Synthesis
79134-11-5
187143-22-2
The general procedure for the synthesis of 6-(methylsulfonyl)-3-pyridinamine from 2-(methylsulfonyl)-5-nitropyridine was as follows: 2-(methylsulfonyl)-5-nitropyridine (1.80 g, 8.90 mmol) was dissolved in a mixed solvent of water (25 mL) and methanol (25 mL). Iron powder (1.49 g, 26.68 mmol) and ammonium chloride (2.86 g, 53.47 mmol) were added. The reaction mixture was heated to reflux temperature and stirred for 1 hour. After completion of the reaction, the mixture was filtered and the solid was washed with ethyl acetate (EtOAc). The filtrate was extracted with ethyl acetate and the organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4). The desiccant was removed by filtration and the filtrate was collected and concentrated under reduced pressure to afford 6-(methylsulfonyl)-3-pyridinamine (1.40 g, 91% yield). The product was analyzed by LC-ES/MS, m/z 173 [M + H]+.
References
[1] Patent: WO2013/66640, 2013, A1. Location in patent: Page/Page column 19
[2] Patent: WO2009/149139, 2009, A1. Location in patent: Page/Page column 58-59
[3] Patent: US6649636, 2003, B1. Location in patent: Page/Page column 52
[4] Journal of the Chemical Society, <1948> 1939, 1944,
[5] Patent: WO2004/48367, 2004, A1. Location in patent: Page 11
6-(Methylsulfonyl)-3-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
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