5-amino-2-bromo-4-methylbenzoic acid
- Product Name
- 5-amino-2-bromo-4-methylbenzoic acid
- CAS No.
- 745048-63-9
- Chemical Name
- 5-amino-2-bromo-4-methylbenzoic acid
- Synonyms
- 3-Amino-6-bromo-4-methylbenzoic acid;5-amino-2-bromo-4-methylbenzoic acid;Benzoic acid, 5-amino-2-bromo-4-methyl-
- CBNumber
- CB72535619
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 745048-63-9.mol
5-amino-2-bromo-4-methylbenzoic acid Property
- Boiling point:
- 380.2±42.0 °C(Predicted)
- Density
- 1.682±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.16±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A576963
- Product name
- 5-Amino-2-bromo-4-methylbenzoicAcid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 1570AC
- Product name
- 5-Amino-2-bromo-4-methylbenzoicacid
- Packaging
- 100mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- HCH0366663
- Product name
- 5-AMINO-2-BROMO-4-METHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.66
- Updated
- 2021/12/16
- Product number
- UT01649
- Product name
- 5-Amino-2-bromo-4-methylbenzoicacid
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $65.18
- Updated
- 2021/12/16
- Product number
- A192324
- Product name
- 5-Amino-2-bromo-4-methylbenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
5-amino-2-bromo-4-methylbenzoic acid Chemical Properties,Usage,Production
Synthesis
2458-12-0
745048-63-9
The general procedure for the synthesis of 5-amino-2-bromo-4-methylbenzoic acid from 3-amino-4-methylbenzoic acid was as follows: 3-amino-4-methylbenzoic acid (24.72 g, 162 mmol) was dissolved in anhydrous DMF (140 mL). Subsequently, the solution was cooled to 0-5 °C and N-bromosuccinimide (29.70 g, 163.5 mmol) was added in batches while keeping the temperature of the reaction mixture below 15 °C. The reaction mixture was stirred under these conditions for 2 hours. Upon completion of the reaction, the mixture was slowly poured into an ice-water mixture (150 g) while stirring was continued. The precipitated solid was collected by filtration and washed with cold water (3 x 120 mL). The resulting filter cake was dissolved in EtOAc (800 mL) and the organic layer was washed with water (3 x 200 mL). The organic layer was subsequently dried with anhydrous magnesium sulfate, filtered and the solvent was removed by vacuum evaporation to afford 5-amino-2-bromo-4-methylbenzoic acid as a pink solid (31.59 g, 85% yield).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2662 - 2675
[2] Patent: WO2011/159067, 2011, A2. Location in patent: Page/Page column 28
[3] Patent: US2007/275907, 2007, A1. Location in patent: Page/Page column 19
[4] Patent: US2008/242596, 2008, A1. Location in patent: Page/Page column 15
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5632 - 5635
5-amino-2-bromo-4-methylbenzoic acid Preparation Products And Raw materials
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