Alda 1

ChemicalBook > CAS DataBase List > Alda 1

Product Name: Alda 1
CAS No.: 349438-38-6
Chemical Name: Alda 1
Synonyms: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide;Alda 1;CS-1573;ALDA1;ALDA 1;ALDH2 Agonist, Alda-1;ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem;Benzamide, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide;Alda-1,Apoptosis,inhibit,Aldehyde Dehydrogenase (ALDH),Inhibitor,Alda1
CBNumber: CB72535659
Molecular Formula: C15H11Cl2NO3
Formula Weight: 324.16
MOL File: 349438-38-6.mol

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Alda 1 Property

Boiling point:: 473.0±45.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL (clear solution)
pka: 12.75±0.46(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T,N
Risk Statements: 25-50
Safety Statements: 45-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0462
Product name: Alda-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Sigma-Aldrich

Product number: 126920
Product name: ALDH2 Agonist, Alda-1
Packaging: 25mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 21555
Product name: Alda-1
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21555
Product name: Alda-1
Purity: ≥98%
Packaging: 50mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0462
Product name: Alda-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $441
Updated: 2024/03/01

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Alda 1 Chemical Properties,Usage,Production

Uses

Alda-1 has been used as an aldehyde dehydrogenase 2 (ALDH2) agonist:

to study its cryoprotective effects on H₂O₂-induced Achilles tendinopathy in mice Achilles tenocytes
to study its protective effects against alcohol-derived DNA damage in ALDH2 knock out mice
to study its effects on cutaneous wound healing in mice

Definition

ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide is a carbonyl compound and an organohalogen compound.

Biological Activity

alda 1 is an activator of aldehyde dehydrogenase 2 (aldh2).alda 1 increases activity of wild-type aldh2*1 and variant aldh2*2 (by ~2-fold and 11-fold respectively), capable of partly restoring mutant aldh2*2 activity, and protective against cardiac ischemia.

Biochem/physiol Actions

Alda-1 is an ALDH2 agonist; cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2. ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. It appears that Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding, but does not improve the nitroglycerin binding affinity of the Asian variant.

in vitro

in the present study , alda-1 increased acetaldehyde oxidation by aldh2*1 and aldh2*2 approximately 1.5- and 6-fold, respectively, regarding gtn bioactivation and the effects of alda-1. to similar extent, alda-1 induced the esterase activities of both enzymes as the coenzyme nad. nad pronounced inhibition occurring at > 5mm, its the effect was biphasic. in the presence of 1 mm nad, alda-1 induced aldh2*2-catalyzed ester hydrolysis 73-fold, whereas the nad-induced activity of aldh2*1 was inhibited on account of 20-fold increased inhibitory potency of nad in the presence of the drug. aldh2*2 displayed 7-fold lower gtn denitrating activity and gtn affinity than aldh2*1, but the rate of nitric oxide formation was only reduced 2-fold. soluble guanylate cyclase (sgc) activation was more pronounced than with wild type aldh2 at saturating gtn. alda-1 caused slight inhibition of gtn denitration, and in the presence of either variant, gtn-induced sgc activation was increased. the present results imply that established aldh2 activities stimulated by alda-1, which improved nad binding but does not improve the gtn binding affinity of the asian variant. in addition, an unexpected discrepancy between gtn reductase activity and sgc activation was revealed, which suggested that gtn denitration and bioactivation may display independent pathways of aldh2-catalyzed gtn biotransformation [1].

in vivo

alda-1 (a high-throughput screen yielded a small-molecule activator of aldh2, administered to rats before an ischemic event) reduced infarct size by 60%, most likely through the inhibition of the formation of cytotoxic aldehydes. thus, pharmacologic enhancement of aldh2 activity may be benefit to patients with wild-type or mutant aldh2 who are subjected to cardiac ischemia, such as during coronary bypass surgery [2].

storage

Store at +4°C

References

[1]. beretta m, gorren ac, wenzl mv, weis r, russwurm m, koesling d, schmidt k, mayer b. characterization of the east asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of alda-1. j biol chem. 2010 jan 8;285(2):943-52.
[2]. chen ch, budas gr, churchill en, disatnik mh, hurley td, mochly-rosen d. activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. science. 2008 sep 12;321(5895):1493-5.

Alda 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Alda 1 manufacturers

Career Henan Chemical Co

Product: Alda 1 349438-38-6
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-01-08

349438-38-6, Alda 1Related Search:

N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide

Alda 1

ALDH2 Agonist, Alda-1

Benzamide, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-

ALDA1;ALDA 1

CS-1573

ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem

Alda-1,Apoptosis,inhibit,Aldehyde Dehydrogenase (ALDH),Inhibitor,Alda1

349438-38-6

Inhibitors

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