KU 60019

Product Name: KU 60019
CAS No.: 925701-46-8
Chemical Name: KU 60019
Synonyms: KU-60019 (KU60019;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
CBNumber: CB72535679
Molecular Formula: C30H33N3O5S
Formula Weight: 547.67
MOL File: 925701-46-8.mol

More

Less

KU 60019 Property

Boiling point:: 786.6±60.0 °C(Predicted)
Density: 1.314±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Store at -20°C
solubility: DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM)
form: A crystalline solid
pka: 13.52±0.20(Predicted)
color: Light yellow to khaki

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17502
Product name: Ku-60019
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 17502
Product name: Ku-60019
Packaging: 25mg
Price: $250
Updated: 2024/03/01

Cayman Chemical

Product number: 17502
Product name: Ku-60019
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 17502
Product name: Ku-60019
Packaging: 10mg
Price: $143
Updated: 2024/03/01

TRC

Product number: K660435
Product name: KU-60019
Packaging: 10mg
Price: $235
Updated: 2021/12/16

More

Less

KU 60019 Chemical Properties,Usage,Production

Description

Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.

Uses

KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

KU 60019 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

KU 60019 Suppliers

China 21 India 1 United Kingdom 2 United States 7 Global 31

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Tocris Bioscience

Tel: --
Fax: --
Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

925701-46-8, KU 60019Related Search:

(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide

2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl

KU-60019 (KU60019

4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-

2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide

925701-46-8