ChemicalBook > CAS DataBase List > KU 60019

KU 60019

Product Name
KU 60019
CAS No.
925701-46-8
Chemical Name
KU 60019
Synonyms
KU-60019 (KU60019;ATM Inhibitor, KU 60019;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
CBNumber
CB72535679
Molecular Formula
C30H33N3O5S
Formula Weight
547.67
MOL File
925701-46-8.mol
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KU 60019 Property

Boiling point:
786.6±60.0 °C(Predicted)
Density 
1.314±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C
solubility 
DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM)
form 
A crystalline solid
pka
13.52±0.20(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17502
Product name
Ku-60019
Packaging
1mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
17502
Product name
Ku-60019
Packaging
25mg
Price
$250
Updated
2024/03/01
Cayman Chemical
Product number
17502
Product name
Ku-60019
Packaging
5mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
17502
Product name
Ku-60019
Packaging
10mg
Price
$143
Updated
2024/03/01
TRC
Product number
K660435
Product name
KU-60019
Packaging
10mg
Price
$235
Updated
2021/12/16
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KU 60019 Chemical Properties,Usage,Production

Description

Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.

Uses

KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

in vivo

Despite PTEN-deficient control tumors reaching a 4-fold increase in size before PTEN wild-type controls, KU-60019-treated PTEN-deficient tumors display a statistically significant slowing in growth. This growth inhibition is especially evident at the start of the experiment (days 5-12) just after KU-60019 is administered (days 1-5)[2].

IC 50

ATM: 6.3 nM (IC50); DNA-PKcs: 1.7 μM (IC50)

References

[1] SARAH E GOLDING. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.[J]. Molecular Cancer Therapeutics, 2009: 2894-2902. DOI: 10.1158/1535-7163.mct-09-0519
[2] SARAH E GOLDING. Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.[J]. Cell Cycle, 2012, 11 6: 1167-1173. DOI: 10.4161/cc.11.6.19576
[3] LAURA BIDDLESTONE-THORPE. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.[J]. Clinical Cancer Research, 2013, 19 12: 3189-3200. DOI: 10.1158/1078-0432.ccr-12-3408
[4] NUALA MCCABE. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.[J]. Cancer research, 2015: 2159-2165. DOI: 10.1158/0008-5472.can-14-3502

KU 60019 Preparation Products And Raw materials

Raw materials

Preparation Products

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KU 60019 Suppliers

China 29 India 1 United Kingdom 2 United States 7 Global 39
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60

925701-46-8, KU 60019Related Search:


  • (2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
  • 2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl
  • KU-60019 (KU60019
  • 4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
  • 2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
  • ATM Inhibitor, KU 60019
  • 925701-46-8