KU 60019
- Product Name
- KU 60019
- CAS No.
- 925701-46-8
- Chemical Name
- KU 60019
- Synonyms
- KU-60019 (KU60019;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
- CBNumber
- CB72535679
- Molecular Formula
- C30H33N3O5S
- Formula Weight
- 547.67
- MOL File
- 925701-46-8.mol
KU 60019 Property
- Boiling point:
- 786.6±60.0 °C(Predicted)
- Density
- 1.314±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Store at -20°C
- solubility
- DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.52±0.20(Predicted)
- color
- Light yellow to khaki
N-Bromosuccinimide Price
- Product number
- 17502
- Product name
- Ku-60019
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 17502
- Product name
- Ku-60019
- Packaging
- 25mg
- Price
- $250
- Updated
- 2024/03/01
- Product number
- 17502
- Product name
- Ku-60019
- Packaging
- 5mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 17502
- Product name
- Ku-60019
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- K660435
- Product name
- KU-60019
- Packaging
- 10mg
- Price
- $235
- Updated
- 2021/12/16
KU 60019 Chemical Properties,Usage,Production
Description
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.
Uses
KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
KU 60019 Preparation Products And Raw materials
Raw materials
Preparation Products
KU 60019 Suppliers
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