tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-)
- Product Name
- tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-)
- CAS No.
- 604010-24-4
- Chemical Name
- tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-)
- Synonyms
- 1-Boc-2,6-dimethylpiperidin-4-one;1-Boc-2,6-Dimethyl-4-oxopiperidine;tert-butyl-2,6-diMethyl-4-oxopiperidine-1-carboxylate;(2S,6S)-tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate;tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate - [B87063];1-Piperidinecarboxylic acid, 2,6-dimethyl-4-oxo-, 1,1-dimethylethyl ester;tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-)
- CBNumber
- CB72537017
- Molecular Formula
- C12H21NO3
- Formula Weight
- 227.3
- MOL File
- 604010-24-4.mol
tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-) Property
- Boiling point:
- 308.2±35.0 °C(Predicted)
- Density
- 1.027±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.46±0.60(Predicted)
- Appearance
- light yellow solid
Safety
- HS Code
- 29333220
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T206155
- Product name
- tert-Butyl2,6-Dimethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T206155
- Product name
- tert-Butyl2,6-Dimethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB167775
- Product name
- 1-Boc-2,6-Dimethyl-4-oxopiperidine
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB167775
- Product name
- 1-Boc-2,6-Dimethyl-4-oxopiperidine
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CHM0393936
- Product name
- TERT-BUTYL-2,6-DIMETHYL-4-OXOPIPERIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.58
- Updated
- 2021/12/16
tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-) Chemical Properties,Usage,Production
Synthesis
45717-87-1
24424-99-5
604010-24-4
Synthesis of tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate (9.37): 2,6-dimethylpiperidin-4-one (9.36, 3.6 g, 28.34 mmol) was dissolved in dichloromethane (DCM, 50 mL) at 0°C. Triethylamine (Et3N, 9.8 mL, 70.8 mmol) and di-tert-butyl dicarbonate ( Boc2O, 12.1 mL, 56.6 mmol). The reaction mixture was stirred at room temperature for 16 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water and extracted (3 times) with DCM. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The crude product was purified by silica gel column chromatography (100-200 mesh, 10-15% ethyl acetate-hexane) to afford the target compound 9.37 (3.9 g, 60.9% yield).1H NMR (400 MHz, CDCl3): δ 2.85 (d, J = 6.4 Hz, 1H), 2.81 (d, J = 6.4 Hz, 1H), 2.38- 2.39 (m, 2H), 2.34-2.36 (m, 2H), 1.48 (s, 9H), 1.25-1.27 (m, 6H). MS: 228.08 (M + H)+.
References
[1] Patent: WO2015/103060, 2015, A1. Location in patent: Paragraph 0359-0360
[2] Patent: WO2016/203112, 2016, A1. Location in patent: Page/Page column 62; 63
tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate (mixtureof cis- and trans-) Preparation Products And Raw materials
Raw materials
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