methyl 4-chloroquinoline-7-carboxylate
- Product Name
- methyl 4-chloroquinoline-7-carboxylate
- CAS No.
- 178984-69-5
- Chemical Name
- methyl 4-chloroquinoline-7-carboxylate
- Synonyms
- methyl 4-chloroquinoline-7-carboxylate;7-Quinolinecarboxylic acid, 4-chloro-, methyl ester
- CBNumber
- CB72537547
- Molecular Formula
- C11H8ClNO2
- Formula Weight
- 221.64
- MOL File
- 178984-69-5.mol
methyl 4-chloroquinoline-7-carboxylate Property
- Boiling point:
- 333.6±22.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.58±0.27(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-W006117
- Product name
- Methyl4-chloroquinoline-7-carboxylate
- Purity
- 96.39%
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-W006117
- Product name
- Methyl4-chloroquinoline-7-carboxylate
- Purity
- 96.39%
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-W006117
- Product name
- Methyl4-chloroquinoline-7-carboxylate
- Purity
- 96.39%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 9379AA
- Product name
- Methyl4-chloroquinoline-7-carboxylate
- Packaging
- 1g
- Price
- $377
- Updated
- 2021/12/16
- Product number
- HCH0369430
- Product name
- METHYL-4-CHLOROQUINOLINE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.37
- Updated
- 2021/12/16
methyl 4-chloroquinoline-7-carboxylate Chemical Properties,Usage,Production
Synthesis
863785-96-0
178984-69-5
General procedure for the synthesis of methyl 4-chloroquinoline-7-carboxylate from methyl 4-oxo-1,4-dihydroquinoline-7-carboxylate: the residue (0.59 g) was dissolved in N,N-dimethylformamide (20 ml), triethylamine (4 ml) and 10% palladium/carbon (0.59 g) were added. The reaction mixture was stirred overnight under hydrogen atmosphere and at room temperature. After completion of the reaction, the mixture was filtered and the filter cake was washed with chloroform. The solvent was removed by distillation under reduced pressure and the residue was washed with methanol to afford methyl 4-oxo-1,4-dihydroquinoline-7-carboxylate (187 mg, 28% yield). The resulting methyl 4-oxo-1,4-dihydroquinoline-7-carboxylate (650 mg) was suspended in diisopropylethylamine (7 ml), phosphorus trichloride (1.5 ml) was added, and the reaction was stirred at 120 °C for 30 min. After completion of the reaction, water was added to the reaction mixture under ice bath cooling. The aqueous layer was neutralized with aqueous sodium bicarbonate and the organic layer was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography in acetone-chloroform system to afford methyl 4-chloroquinoline-7-carboxylate (609 mg, 86% yield).
References
[1] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 76
methyl 4-chloroquinoline-7-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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