ChemicalBook > CAS DataBase List > GW 803430

GW 803430

Product Name
GW 803430
CAS No.
515141-51-2
Chemical Name
GW 803430
Synonyms
GW 3430;GW 803430;GW-803430A;GW 803430,GW803430;GW-803430 >=98% (HPLC);Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy];6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one;6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
CBNumber
CB72538276
Molecular Formula
C25H24ClN3O3S
Formula Weight
481.99
MOL File
515141-51-2.mol
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GW 803430 Property

Boiling point:
677.7±65.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥4mg/mL at warmed to 60°C
form 
powder
pka
9.52±0.20(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0230
Product name
GW-803430
Purity
≥98% (HPLC)
Packaging
5mg
Price
$85.9
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0230
Product name
GW-803430
Purity
≥98% (HPLC)
Packaging
25mg
Price
$504
Updated
2022/05/15
Cayman Chemical
Product number
13948
Product name
GW 803430
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
13948
Product name
GW 803430
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
13948
Product name
GW 803430
Packaging
10mg
Price
$214
Updated
2024/03/01
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GW 803430 Chemical Properties,Usage,Production

Uses

GW 803430 is a melanin-concentrating hormone receptor 1( MCH1) antagonist for treatment of obesity and depression.

Biochem/physiol Actions

GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice. It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.

in vivo

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls[1].
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice[1].

Animal Model:High fat diet-induced obese AKR/J mice[1]
Dosage:0.3, 3, and 15 mg/kg
Administration:Orally, qd,12 days
Result:Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.

storage

Store at -20°C

GW 803430 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW 803430 Suppliers

China 29 United Kingdom 1 United States 10 Global 40
Sigma-Aldrich
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Shanghai Lollane Biological Technology Co.,Ltd.
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Guangzhou Younan Technology Co., Ltd
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Energy Chemical
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Beijing Jin Ming Biotechnology Co., Ltd.
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Hubei Kele Fine Chemical Co., Ltd
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Wuhan Augda Biotechnology Co., Ltd
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TargetMol Chemicals Inc.
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Henan Alpha Chemical Co., Ltd.
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Xianning Shen Lan Biomedical Research and Development Co., Ltd.
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Nantong QuanYi Biotechnology Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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Cayman Chemical Company
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Merck KGaA
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Santa Cruz Biotechnology Inc
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Guangzhou Haotian Biotechnology Co., Ltd.
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Foshan Minghua Biotechnology Co., Ltd.
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Guangzhou Qiansheng Biotechnology Co., Ltd.
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Neobioscience Co., Ltd.
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Absin Bioscience Inc.
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515141-51-2, GW 803430Related Search:


  • Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]
  • Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
  • GW 803430
  • GW 3430
  • 6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
  • GW-803430A
  • 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
  • GW-803430 >=98% (HPLC)
  • GW 803430,GW803430
  • 515141-51-2