ChemicalBook > CAS DataBase List > N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide

Product Name
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
CAS No.
1199236-64-0
Chemical Name
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
Synonyms
Z-944;Ulixacaltamide;Ulixacaltamide (Z944);N-[[1-[2-(tert-butylamino)-2-;Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit;N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide;4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide;1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
CBNumber
CB72543885
Molecular Formula
C19H27ClFN3O2
Formula Weight
383.89
MOL File
1199236-64-0.mol
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N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Property

Melting point:
122-124°C
Boiling point:
528.1±50.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.65±0.46(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27679
Product name
Z944
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
25mg
Price
$571
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
10mg
Price
$243
Updated
2024/03/01
Tocris
Product number
6367
Product name
Z944
Purity
≥98%(HPLC)
Packaging
10
Price
$223
Updated
2021/12/16
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N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Chemical Properties,Usage,Production

Description

Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.

Chemical Properties

White Solid

Uses

As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.

Definition

ChEBI: Ulixacaltamide is a member of piperidines, a member of benzamides, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. It has a role as a T-type calcium channel blocker and a non-narcotic analgesic.

storage

Store at +4°C

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Suppliers

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1199236-64-0, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMideRelated Search:


  • 4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide
  • N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
  • Z-944
  • 1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
  • N-[[1-[2-(tert-butylamino)-2-
  • Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit
  • Ulixacaltamide (Z944)
  • Ulixacaltamide
  • 1199236-64-0
  • C19H27ClFN3O2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals