ChemicalBook > CAS DataBase List > N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide

Product Name
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
CAS No.
1199236-64-0
Chemical Name
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
Synonyms
Z-944;Ulixacaltamide;Ulixacaltamide (Z944);N-[[1-[2-(tert-butylamino)-2-;Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit;N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide;4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide;1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
CBNumber
CB72543885
Molecular Formula
C19H27ClFN3O2
Formula Weight
383.89
MOL File
1199236-64-0.mol
More
Less

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Property

Melting point:
122-124°C
Boiling point:
528.1±50.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.65±0.46(Predicted)
form 
Solid
color 
White to Off-White
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27679
Product name
Z944
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
25mg
Price
$571
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
27679
Product name
Z944
Packaging
10mg
Price
$243
Updated
2024/03/01
Tocris
Product number
6367
Product name
Z944
Purity
≥98%(HPLC)
Packaging
50
Price
$936
Updated
2021/12/16
More
Less

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Chemical Properties,Usage,Production

Description

Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.

Chemical Properties

White Solid

Uses

As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.

Definition

ChEBI: Ulixacaltamide is a member of piperidines, a member of benzamides, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. It has a role as a T-type calcium channel blocker and a non-narcotic analgesic.

storage

Store at +4°C

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Suppliers

Canada 1 China 28 India 1 United Kingdom 1 United States 7 Global 38
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9756
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9507
Advantage
60
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55896
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
879
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9414
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19690
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
2414
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
2717893647 14768611851
Email
486064515@qq.com
Country
China
ProdList
1050
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31163
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24023
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
5060
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb5@aikonchem.com
Country
China
ProdList
10529
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5019
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48467
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43348
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58

1199236-64-0, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMideRelated Search:


  • 4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide
  • N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
  • Z-944
  • 1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
  • N-[[1-[2-(tert-butylamino)-2-
  • Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit
  • Ulixacaltamide (Z944)
  • Ulixacaltamide
  • 1199236-64-0
  • C19H27ClFN3O2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals