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ADX-47273

Product Name
ADX-47273
CAS No.
851881-60-2
Chemical Name
ADX-47273
Synonyms
CS-221;ADX-47273;BA 94673139;ADX47273, >98%;ADX-47273;ADX47273;ADX-47273 USP/EP/BP;ADX-47273 >=98% (HPLC);ADX-47273 (BA 94673139);(3S)-3-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(4-fluorophenyl)carbonyl]piperidine;(S)-(4-Fluorophenyl)-{3-[3-(4-fluorophenyl)-[1,2,4]oxadiazol-5-yl]piperidin-1-yl}methanone
CBNumber
CB72546765
Molecular Formula
C20H17F2N3O2
Formula Weight
369.36
MOL File
851881-60-2.mol
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ADX-47273 Property

Boiling point:
540.8±60.0 °C(Predicted)
Density 
1.311
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
-0.83±0.44(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2271
Product name
ADX-47273
Purity
≥98% (HPLC)
Packaging
5MG
Price
$79
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2271
Product name
ADX-47273
Purity
≥98% (HPLC)
Packaging
25MG
Price
$319
Updated
2024/03/01
Cayman Chemical
Product number
17987
Product name
ADX47273
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
17987
Product name
ADX47273
Purity
≥98%
Packaging
5mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
17987
Product name
ADX47273
Purity
≥98%
Packaging
10mg
Price
$437
Updated
2024/03/01
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ADX-47273 Chemical Properties,Usage,Production

Description

ADX-47273 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with EC50 values of 0.17 and 0.23 μM for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures, respectively. It is selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 when used at concentrations up to 10 μM. In vivo, ADX-47273 (1 and 10 mg/kg, i.p.) increases ERK and CREB phosphorylation in the hippocampus and prefrontal cortex in rats. It decreases the conditioned avoidance response, apomorphine-induced climbing, as well as PCP-, apomorphine-, and amphetamine-induced locomotor activity in rats in a dose-dependent manner, indicating antipsychotic-like activity. ADX-47273 (0.1-50 mg/kg, i.p) improves recall in a novel object recognition test and reduces impulsivity in the 5-choice serial reaction time task (5CSRTT). It also enhances reversal learning in mice in the Morris water maze test.

in vivo

adx47273 increased erk (extracellular signal-regulated kinase) and creb (camp-responsive element-binding protein) phosphorylation in rat hippocampus and prefrontal cortex. in rat and mouse models that sensitive to antipsychotic treatment, adx47273 decreased rat conditioned avoidance responding (minimal effective dose = 30 mg/kg i.p.) and reduced mouse ampomorphine-activated climbing (minimal effective dose = 100 mg/kg i.p.) [1]

References

[1] liu f, grauer s, kelley c, navarra r, graf r, zhang g, atkinson pj, popiolek m, wantuch c, khawaja x, smith d, olsen m, kouranova e, lai m, pruthi f, pulicicchio c, day m, gilbert a, pausch mh, brandon nj, beyer ce, comery ta, logue s, rosenzweig-lipson s, marquis kl. adx47273 [s-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and precognitive activities. j pharmacol exp ther. 2008 dec;327(3):827-39.

ADX-47273 Preparation Products And Raw materials

Raw materials

Preparation Products

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ADX-47273 Suppliers

China 76 India 1 United Kingdom 1 United States 15 Global 93
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from ADX-47273 manufacturers

Career Henan Chemical Co
Product
ADX-47273 851881-60-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

851881-60-2, ADX-47273Related Search:

Sulfanilamide Lignosulfonic acid Angeli’s Salt TRIS(PENTAFLUOROPHENYL)PHOSPHINE 2-FLUOROPHENYL CYCLOPENTYL KETONE (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XEN445

  • ADX-47273
  • (S)-(4-Fluorophenyl)-{3-[3-(4-fluorophenyl)-[1,2,4]oxadiazol-5-yl]piperidin-1-yl}methanone
  • BA 94673139
  • ADX47273, >98%
  • ADX-47273;ADX47273
  • CS-221
  • ADX-47273 >=98% (HPLC)
  • (3S)-3-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(4-fluorophenyl)carbonyl]piperidine
  • ADX-47273 USP/EP/BP
  • ADX-47273 (BA 94673139)
  • Methanone, (4-fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-
  • 851881-60-2
  • C20H17F2N3O2
  • Inhibitors