ethyl 2.4-dioxo-4-p-tolylbutanoate
- Product Name
- ethyl 2.4-dioxo-4-p-tolylbutanoate
- CAS No.
- 5814-37-9
- Chemical Name
- ethyl 2.4-dioxo-4-p-tolylbutanoate
- Synonyms
- Ethyl 2,4-dioxo-4-(p-tolyl);ethyl 2.4-dioxo-4-p-tolylbutanoate;Ethyl 4-methyl-α,γ-dioxobenzenebutanoate;Ethyl 4-methyl-α,γ-dioxobenzenebutanoate;Ethyl 4-Methyl-a,g-dioxo-benzenebutanoate;Benzenebutanoic acid, 4-methyl-α,γ-dioxo-, ethyl ester;Benzenebutanoic acid, 4-Methyl-.alpha.,.gaMMa.-dioxo-, ethyl ester
- CBNumber
- CB72548143
- Molecular Formula
- C13H14O4
- Formula Weight
- 234.25
- MOL File
- 5814-37-9.mol
ethyl 2.4-dioxo-4-p-tolylbutanoate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8601AB
- Product name
- Ethyl2,4-dioxo-4-(p-tolyl)butanoate
- Packaging
- 25g
- Price
- $1171
- Updated
- 2021/12/16
- Product number
- A102402
- Product name
- Ethyl2,4-dioxo-4-(p-tolyl)butanoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- A102402
- Product name
- Ethyl2,4-dioxo-4-(p-tolyl)butanoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- JL-14C-005
- Product name
- 2,4-Dioxo-4-p-tolyl-butyricacidethylester
- Purity
- 95%+
- Packaging
- 500mg
- Price
- $26.1
- Updated
- 2021/12/16
- Product number
- A102402
- Product name
- Ethyl2,4-dioxo-4-(p-tolyl)butanoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
ethyl 2.4-dioxo-4-p-tolylbutanoate Chemical Properties,Usage,Production
Synthesis
122-00-9
95-92-1
5814-37-9
(1) In a 250-mL three-necked flask, 24 g (0.348 mol) of sodium ethoxide and 200 mL of anhydrous toluene were added and mixed with stirring. Subsequently, 45.6 g (0.34 mol) of 4'-methylacetophenone was added slowly and dropwise over a period of 30 minutes to ensure uniform mixing. Next, 51.0 g (0.348 mol) of diethyl oxalate was added. After dropwise addition, the reaction mixture was heated to 50-60°C and stirred continuously for 4 hours. Upon completion of the reaction, it was cooled to room temperature, washed with 5% dilute hydrochloric acid solution and the pH was adjusted to the appropriate value. Liquid-liquid separation was carried out and the toluene layer was collected and dried with anhydrous sodium sulfate for 30 minutes. After filtration, the filtrate was distilled under reduced pressure to recover toluene. The residue was recrystallized from 95% ethanol to give 73.3 g of Intermediate 1 (purity: 99.1%) in 92% yield.
References
[1] Patent: CN108148003, 2018, A. Location in patent: Paragraph 0144; 0145; 0150; 0151; 0156; 0157; 0162; 0163
[2] Synthetic Communications, 2013, vol. 43, # 1, p. 110 - 117
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 4720 - 4725
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 20, p. 4248 - 4251
[5] Annales de Chimie (Cachan, France), 1938, vol. <11> 9, p. 447,491
ethyl 2.4-dioxo-4-p-tolylbutanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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