Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Uses- Product Name
- Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate
- CAS No.
- 30062-34-1
- Chemical Name
- Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate
- Synonyms
- methyl 6-hydroxypicolinate;6-Methoxycarbonyl-2-pyridone;methyl 6-oxo-1H-pyridine-2-carboxylate;methyl 6-hydroxypicolinate hydrochloride;Methyl -oxo-1,6-dihydropyridine-2-carboxylate;Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate;Methvl 6-oxo-1.6-dihydropvridine-2-carboxylate;2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-, methyl ester;Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate, methyl 6-hydroxypyridine-2-carboxylate
- CBNumber
- CB72549665
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 30062-34-1.mol
Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate Property
- Melting point:
- 109-110 °C
- Boiling point:
- 367.6±42.0 °C(Predicted)
- Density
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.83±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H7NO3/c1-11-7(10)5-3-2-4-6(9)8-5/h2-4H,1H3,(H,8,9)
- InChIKey
- GJLWQAUHCDNAEK-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)NC(=O)C=CC=1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M219575
- Product name
- Methyl6-Oxo-1,6-dihydropyridine-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3110AB
- Product name
- Methyl6-oxo-1,6-dihydropyridine-2-carboxylate
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 231201
- Product name
- Methyl6-oxo-1,6-dihydropyridine-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- OR955459
- Product name
- Methyl6-hydroxypyridine-2-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR955459
- Product name
- Methyl6-hydroxypyridine-2-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $370
- Updated
- 2021/12/16
Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate, as an important pharmaceutical intermediate and fine chemical raw material, has a wide range of applications and a broad market prospect. In the pharmaceutical field, 2-pyridinemethanol, as an important pharmaceutical intermediate, can be used to synthesize bisacodyl, a blood transfusion drug, and is also a raw material for synthesizing pralidoxime, an organophosphate antidote.
Synthesis
67-56-1
19621-92-2
30062-34-1
Step 1: Synthesis of methyl 6-hydroxypyridine-2-carboxylate. 6-Hydroxypyridine-2-carboxylic acid (13.0 g, 93.5 mmol) was dissolved in methanol (150 mL) at room temperature and a dioxane solution of 4N HCl (10 mL) was slowly added. The reaction mixture was stirred at room temperature for 48 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford methyl 6-hydroxypyridine-2-carboxylate (13 g, 90% yield) as a white solid.
References
[1] Patent: WO2004/37808, 2004, A1. Location in patent: Page 19-20
[2] Patent: WO2014/154727, 2014, A1. Location in patent: Page/Page column 38; 52
[3] Patent: US2014/296239, 2014, A1. Location in patent: Paragraph 0097; 0098
[4] Patent: WO2014/154726, 2014, A1. Location in patent: Page/Page column 38-39
[5] Patent: US2014/296296, 2014, A1. Location in patent: Paragraph 0106; 0107
Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate manufacturers
- Product
- Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate 30062-34-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-18
- Product
- Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate 30062-34-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23