Benzo[d]isoxazol-5-ylaMine
- Product Name
- Benzo[d]isoxazol-5-ylaMine
- CAS No.
- 239097-74-6
- Chemical Name
- Benzo[d]isoxazol-5-ylaMine
- Synonyms
- BENZO[D]ISOXAZOL-5-AMINE;1,2-benzoxazol-5-amine;5-Aminobenzo[d]isoxazole;1,2-benzisoxazol-5-amine;1,2-Benzoisoxazol-5-amine;Benzo[d]isoxazol-5-ylaMine;Benzo[d]isoxazol-5-ylamine(AK-64412)
- CBNumber
- CB72550337
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 239097-74-6.mol
Benzo[d]isoxazol-5-ylaMine Property
- Boiling point:
- 311.6±15.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.67±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB143763
- Product name
- Benzo[d]isoxazol-5-amine
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB143763
- Product name
- Benzo[d]isoxazol-5-amine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB143763
- Product name
- Benzo[d]isoxazol-5-amine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB143763
- Product name
- Benzo[d]isoxazol-5-amine
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB143763
- Product name
- Benzo[d]isoxazol-5-amine
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
Benzo[d]isoxazol-5-ylaMine Chemical Properties,Usage,Production
Synthesis
39835-28-4
239097-74-6
GENERAL STEPS: To a 12M HCl (0.5 mL) solution of SnCl4 (1.828 g, 7.02 mmol) under stirring was added 5-nitro-1,2-benzisoxazole (140 mg, 0.86 mmol) in a single addition at 0 °C. After a few minutes of reaction, a 12M HCl (0.5 mL) solution of SnCl2-2H2O (792 mg, 3.51 mmol) was added slowly and dropwise at 0 °C, followed by the addition of 12M HCl (1.0 mL). The reaction mixture was brought to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, the reaction mixture was extracted with Et2O. The aqueous phase was adjusted to pH ~8 with saturated NaHCO3 solution and subsequently extracted with EtOAc. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated, and dried in vacuum to give 1,2-benzisoxazol-5-amine as a colorless solid (110 mg, 95% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.54 (s, 1H), 7.42 (d, J=8.4 Hz, 1H), 6.94 (dd, J=8.4 Hz, 2.0 Hz, 1H), 6.91 (d, J=2.0 Hz, 1H). es-MS m/z: 135.1 [M+H]+. lc-MS analysis Shows purity of 90% (214 nm), retention time tR = 1.32 min.
References
[1] Patent: WO2016/73889, 2016, A1. Location in patent: Paragraph 00229
[2] Patent: WO2016/73895, 2016, A1. Location in patent: Paragraph 00286
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 18, p. 6189 - 6196
Benzo[d]isoxazol-5-ylaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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