4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine

Product Name: 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine
CAS No.: 10244-24-3
Chemical Name: 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine
Synonyms: 100056;EOS-61273;6-Chloro-2,4-di(4-morpholinyl);4-chloro-2,6-diMorpholinopyriMidine;2,4-Dimorpholino-6-chloropyrimidine;6-Chloro-2,4-di(4-morpholinyl)pyrimidine;6-Chloro-2,4-bis(4-Morpholinyl)pyriMidine;-(6-Chloropyrimidine-2,4-diyl)dimorpholine;2,4-Bis(morpholin-4-yl)-6-chloropyrimidine;4,4'-(6-chloropyrimidine-2,4-diyl)dimorpholine
CBNumber: CB72552715
Molecular Formula: C12H17ClN4O2
Formula Weight: 284.74
MOL File: 10244-24-3.mol

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4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Property

Melting point:: 139-142℃
Boiling point:: 508.7±60.0 °C(Predicted)
Density: 1.327±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 6.10±0.50(Predicted)
Appearance: White to light yellow Solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00039
Product name: 2,4-Dimorpholino-6-chloropyrimidine
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $216
Updated: 2025/07/31

TRC

Product number: B405390
Product name: 4,4''-(6-Chloropyrimidine-2,4-diyl)dimorpholine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR303956
Product name: 4-[4-Chloro-6-(morpholin-4-yl)pyrimidin-2-yl]morpholine
Packaging: 500mg
Price: $135
Updated: 2021/12/16

Apolloscientific

Product number: OR303956
Product name: 4-[4-Chloro-6-(morpholin-4-yl)pyrimidin-2-yl]morpholine
Packaging: 1g
Price: $173
Updated: 2021/12/16

Matrix Scientific

Product number: 071111
Product name: 4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine
Purity: 95%
Packaging: 1g
Price: $198
Updated: 2021/12/16

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4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Chemical Properties,Usage,Production

Synthesis

110-91-8

3764-01-0

10244-24-3

The general procedure for the synthesis of 2,4-bis(4-morpholinyl)-6-chloropyrimidine from morpholine (12.6 mL, 144 mmol) and 2,4,6-trichloropyrimidine (4.4 g, 24 mmol) was as follows: first, the morpholine was dissolved in a mixture of toluene (22 mL) and water (8.8 mL) as solvent. Subsequently, 2,4,6-trichloropyrimidine was dissolved in toluene (22 mL) and slowly added dropwise to the morpholine solution. The reaction mixture was stirred and heated to 83°C at room temperature and maintained for 3 hours. After completion of the reaction, it was cooled to room temperature and phase separation was carried out. The organic phase was washed with 10 mol/L hydrochloric acid and then dried with anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography, and the eluent was a mixed solvent of petroleum ether and ethyl acetate (1:1, v/v), which ultimately afforded 2,4-bis(4-morpholinyl)-6-chloropyrimidine (6.68 g, 98% yield).

References

[1] Patent: CN105461714, 2016, A. Location in patent: Paragraph 0244; 0245; 0246
[2] Patent: CN105541792, 2016, A. Location in patent: Paragraph 0226; 0227; 0228
[3] Patent: US2016/264546, 2016, A1. Location in patent: Paragraph 0033
[4] Patent: WO2012/44727, 2012, A2. Location in patent: Page/Page column 62-63
[5] Australian Journal of Chemistry, 2002, vol. 55, # 3, p. 205 - 212

4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine Suppliers

China 86 India 1 United Kingdom 2 United States 6 Global 95

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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Country: China
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

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Shanghai XinKai Chemical Technology Co., Ltd.

Tel: 021-58930698 15921516558
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Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
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View Lastest Price from 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine 10244-24-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Bis(morpholin-4-yl)-6-chloropyrimidine 10244-24-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholine 10244-24-3
Price: US $6.60/KG
Min. Order: 500g
Purity: 98%
Supply Ability: 1kg, 50kg, 100kg
Release date: 2019-12-25

10244-24-3, 4,4'-(6-chloropyriMidine-2,4-diyl)diMorpholineRelated Search:

6-Chloro-2,4-bis(4-Morpholinyl)pyriMidine

4-chloro-2,6-diMorpholinopyriMidine

2,4-Bis(morpholin-4-yl)-6-chloropyrimidine

100056

6-Chloro-2,4-di(4-morpholinyl)

-(6-Chloropyrimidine-2,4-diyl)dimorpholine

6-Chloro-2,4-di(4-morpholinyl)pyrimidine

2,4-Dimorpholino-6-chloropyrimidine

EOS-61273

4-[6-Chloro-2-(morpholin-4-yl)pyrimidin-4-yl]morpholine

Morpholine, 4,4'-(6-chloro-2,4-pyriMidinediyl)bis-

4-[4-Chloro-6-(morpholin-4-yl)pyrimidin-2-yl]morpholine

4,4'-(6-chloropyrimidine-2,4-diyl)dimorpholine

4,4'-(6-chloropyrimidine-2,4-diyl)dimorpholine - [C16086]

10244-24-3