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2-Butenoic acid, 4,4-

Product Name
2-Butenoic acid, 4,4-
CAS No.
114736-25-3
Chemical Name
2-Butenoic acid, 4,4-
Synonyms
Minodronic Impurity 6;2-Butenoic acid, 4,4-;Minodronic Acid Impurity 17;ethyl 4,4-diMethoxybut-2-enoate;Ethyl(E)-4,4-dimethoxybut-2-enoate;Ethyl (E)-4,4-dimethoxy-2-butenoate;(E)-Ethyl 4,4-DiMethoxybut-2-enoate;4,4-Dimethoxybut-2-enoic acid ethyl ester;2-Butenoic acid, 4,4-diMethoxy-, ethyl ester;(E)-4,4-Dimethoxy-2-butenoic acid ethyl ester
CBNumber
CB72554072
Molecular Formula
C8H14O4
Formula Weight
174.19
MOL File
114736-25-3.mol
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2-Butenoic acid, 4,4- Property

Boiling point:
222℃
Density 
1.019
Flash point:
88℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
color 
Clear Colourless
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E916595
Product name
(E)-Ethyl4,4-Dimethoxybut-2-enoate
Packaging
1g
Price
$150
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0392158
Product name
(E)-ETHYL 4,4-DIMETHOXYBUT-2-ENOATE
Purity
95.00%
Packaging
5MG
Price
$503.82
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
70132
Product name
(E)-Ethyl4,4-Dimethoxybut-2-enoate
Packaging
10g
Price
$2200
Updated
2021/12/16
Ambeed
Product number
A113235
Product name
(E)-Ethyl4,4-dimethoxybut-2-enoate
Purity
95%
Packaging
25g
Price
$247
Updated
2021/12/16
Crysdot
Product number
CD13026361
Product name
(E)-Ethyl4,4-dimethoxybut-2-enoate
Purity
95+%
Packaging
5g
Price
$277
Updated
2021/12/16
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2-Butenoic acid, 4,4- Chemical Properties,Usage,Production

Uses

(E)-Ethyl 4,4-Dimethoxybut-2-enoate has been used as a reactant for the synthesis of N-substituted-1,2,3,6-tetrahydro-pyridine-4-carbaldehyde, a precursor for synthesizing Aricept.

Synthesis

867-13-0

51673-84-8

19255-60-8

General procedure for the synthesis of ethyl 4,4-dimethoxy-but-2-enoate from triethyl phosphonoacetate and glyoxal dimethyl acetal: In a solvent mixture of 210 mL of tetrahydrofuran and 30 mL of water, potassium carbonate (16.5 g, 120 mmol), glyoxal dimethyl acetal (60% wt. aqueous solution, 15 mL, 100 mmol) and triethyl phosphonoacetate (20 mL, 100 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was poured into ether (200 mL) and washed with saturated aqueous sodium chloride. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product ethyl 4,4-dimethoxy-but-2-enoate as a yellow oil (15.8 g, 90% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 6.77 (dd, J = 15.9, 4.0 Hz, 1H), 6.13 (dd, J = 15.9, 1.4 Hz, 1H), 4.95 (dd, J = 4.0, 1.4 Hz, 1H), 4.22 (q, J = 7.1 Hz, 2H), 3.34 (s , 6H), 1.30 (t, J = 7.1 Hz, 3H).

References

[1] Chemical Communications, 2012, vol. 48, # 63, p. 7790 - 7792
[2] Patent: US2010/261712, 2010, A1
[3] Patent: WO2009/60197, 2009, A1. Location in patent: Page/Page column 139-140

2-Butenoic acid, 4,4- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Butenoic acid, 4,4- Suppliers

China 79 India 2 United Kingdom 1 United States 3 Global 85
J & K SCIENTIFIC LTD.
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114736-25-3, 2-Butenoic acid, 4,4-Related Search:


  • 2-Butenoic acid, 4,4-
  • (2E)-4,4-Dimethoxybut-2-enoic acid ethyl ester
  • (E)-4,4-Dimethoxy-2-butenoic acid ethyl ester
  • Ethyl (E)-4,4-dimethoxy-2-butenoate
  • 2-Butenoic acid, 4,4-diMethoxy-, ethyl ester
  • (E)-Ethyl 4,4-DiMethoxybut-2-enoate
  • ethyl 4,4-diMethoxybut-2-enoate
  • Ethyl(E)-4,4-dimethoxybut-2-enoate
  • 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester, (E)-
  • Minodronic Impurity 6
  • Minodronic Acid Impurity 17
  • 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester, (2E)-
  • 4,4-Dimethoxybut-2-enoic acid ethyl ester
  • 114736-25-3