tert-butyl benzo[b]thiophen-2-ylcarbaMate

Product Name: tert-butyl benzo[b]thiophen-2-ylcarbaMate
CAS No.: 89673-36-9
Chemical Name: tert-butyl benzo[b]thiophen-2-ylcarbaMate
Synonyms: tert-butyl benzo[b]thiophen-2-ylcarbaMate;tert-Butyl N-(1-benzothiophen-2-yl)carbamate;Benzothiophene-2-carbamic acid tert-butyl ester;Benzo[b]thien-2-yl-carbamic acid tert-butyl ester;Carbamic acid, N-benzo[b]thien-2-yl-, 1,1-dimethylethyl ester
CBNumber: CB72561382
Molecular Formula: C13H15NO2S
Formula Weight: 249.33
MOL File: 89673-36-9.mol

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tert-butyl benzo[b]thiophen-2-ylcarbaMate Property

Melting point:: 100-101 °C(Solv: ethanol (64-17-5))
Boiling point:: 333.4±15.0 °C(Predicted)
Density: 1.234
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 13.52±0.43(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T135765
Product name: tert-ButylBenzo[b]thiophen-2-ylcarbamate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141204
Product name: tert-Butyl benzo[b]thiophen-2-ylcarbamate
Packaging: 50mg
Price: $56
Updated: 2021/12/16

AK Scientific

Product number: Z5299
Product name: tert-Butylbenzo[b]thiophen-2-ylcarbamate
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141204
Product name: tert-Butyl benzo[b]thiophen-2-ylcarbamate
Packaging: 100mg
Price: $98
Updated: 2021/12/16

AK Scientific

Product number: Z5299
Product name: tert-Butylbenzo[b]thiophen-2-ylcarbamate
Packaging: 1g
Price: $132
Updated: 2021/12/16

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tert-butyl benzo[b]thiophen-2-ylcarbaMate Chemical Properties,Usage,Production

Synthesis

6314-28-9

75-65-0

89673-36-9

Benzo[b]thiophene-2-carboxylic acid (1-A, 14.4 g, 80.6 mmol) was used as starting material and mixed with N,N-diisopropylethylamine (15.5 mL, 88.6 mmol) and diphenylphosphoryl azide (20.8 mL, 96.7 mmol) in tert-butanol (150 mL). The reaction mixture was heated to reflux for 8 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation. The resulting residue was purified by silica gel fast column chromatography using dichloromethane as eluent to afford the target product tert-butyl benzo[b]thiophene-2-yl-carbamate (1-B) as a colorless solid (18.9 g, 94% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6) and mass spectrometry (MS): 1H-NMR (DMSO-d6) δ 1.50 (s, 9H), 6.78 (s, 1H), 7.16 (d, J=7.5Hz, 1H), 7.27 (d, J=7.5Hz, 1H), 7.58 (d, J=7.5Hz, 1H), 7.77 ( d, J=7.5Hz, 1H), 10.70 (br s, 1H); MS: m/z 250.2 (MH+).

References

[1] Patent: WO2009/12430, 2009, A1. Location in patent: Page/Page column 180-181
[2] Patent: US2010/160289, 2010, A1. Location in patent: Page/Page column 24-25
[3] Patent: US2012/190674, 2012, A1. Location in patent: Page/Page column 73
[4] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 193
[5] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 125

tert-butyl benzo[b]thiophen-2-ylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl benzo[b]thiophen-2-ylcarbaMate Suppliers

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89673-36-9