ChemicalBook > CAS DataBase List > KW-2478
KW-2478
- Product Name
- KW-2478
- CAS No.
- 819812-04-9
- Chemical Name
- KW-2478
- Synonyms
- CS-287;KW-2478;KW-2478（b）;KW-2478 USP/EP/BP;KW2478; KW-2478; KW 2478.;2-(2-Ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxye;2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide;2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide;Benzeneacetamide, 2-ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]-
- CBNumber
- CB72561483
- Molecular Formula
- C30H42N2O9
- Formula Weight
- 574.66
- MOL File
- 819812-04-9.mol
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KW-2478 Property
- Density
- 1.209
- storage temp.
- Store at -20°C
- solubility
- ≥100 mg/mL in DMSO
- form
- solid
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22418
- Product name
- KW 2478
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22418
- Product name
- KW 2478
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22418
- Product name
- KW 2478
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22418
- Product name
- KW 2478
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $692
- Updated
- 2024/03/01
TRC
- Product number
- K660453
- Product name
- KW-2478
- Packaging
- 25mg
- Price
- $935
- Updated
- 2021/12/16
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KW-2478 Chemical Properties,Usage,Production
Uses
KW-2478 is a novel non-ansamycin potent Hsp90 inhibitor.
Biological Activity
kw-2478 is a novel and potent nonansamycin inhibitor of heat shock protein 90 (hsp90) to overcome the limitations, including low water solubility and hepatotoxicity, of 17-allylamino-17-demethoxygeldanamycin (17-aag). kw-2478 exerts a strong antitumor activity against multiple myeloma (mm) cells with various chromosormal translocation, in which kw-2478 inhibits cell growth and apoptosis associated with hsp90 client protein degradation and the decreasing of igh translocation products including fgfr3, c-maf and cyclin d1. recent study results have revealed that kw-2478 is able to deplete hsp90 client cdk9 and the phosphorylated 4e-bp1, a transcriptional kinase and a transcription inhibitor respectively, leading to the reduced expression of c-maf and cyclin d1.nakashima t, ishii t, tagaya h, seike t, nakagawa h, kanda y, akinaga s, soga s, shiotsu y. new molecular and biological mechanism of antitumor activities of kw-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells. clin cancer res. 2010; 16(10): 2792-802.
target
Hsp90
KW-2478 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from KW-2478 manufacturers
Career Henan Chemical Co
- Product
- KW-2478 819812-04-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-10
819812-04-9, KW-2478Related Search:
BIIB-021
PF-04929113
4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
17-DMAG
NVP-BEP800
17-AAG