2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Product Name: 2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
CAS No.: 479411-93-3
Chemical Name: 2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
Synonyms: 3-Methoxy-5-trifluoromethylphenylboronic acid, pinacol ester;2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane;1,3,2-Dioxaborolane, 2-[3-methoxy-5-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-
CBNumber: CB72564525
Molecular Formula: C14H18BF3O3
Formula Weight: 302.1
MOL File: 479411-93-3.mol

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2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane Property

storage temp.: 2-8°C
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332268
Product name: 2-(3-Methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V6124
Product name: 3-Methoxy-5-trifluoromethylphenylboronicacidpinacolester
Packaging: 1g
Price: $157
Updated: 2021/12/16

Ambeed

Product number: A115949
Product name: 2-(3-Methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: 97%
Packaging: 1g
Price: $30
Updated: 2021/12/16

Chemenu

Product number: CM214605
Product name: 2-(3-Methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: 95+%
Packaging: 1g
Price: $78
Updated: 2021/12/16

Ambeed

Product number: A115949
Product name: 2-(3-Methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: 97%
Packaging: 5g
Price: $144
Updated: 2021/12/16

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2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane Chemical Properties,Usage,Production

Synthesis

454-90-0

73183-34-3

479411-93-3

The general procedure for the synthesis of 2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolanes from m-trifluoromethyl anisole and bis(pinacolato)boronic acid esters was as follows: to a flame-dried 100 mL Schlenk tube were added sequentially bis(pinacolato)diboron (350 mg, 1.38 mmol), [Ir( COD)Cl]2 (12 mg, 0.018 mmol), sodium methanol (5 mg, 0.09 mmol), and 4,4'-di-tert-butyl-2,2'-bipyridine (8 mg, 0.03 mmol). The flask was evacuated and filled with argon for protection, followed by the addition of 3-trifluoromethylanisole (2.5 mL). The flask was again evacuated (complete vacuum for 2 min), then sealed under vacuum and placed in a 90 °C oil bath for 96 h of reaction. Upon completion of the reaction, the reaction mixture was transferred to a round bottom flask using ethyl acetate and purified by Kugelrohr distillation. The resulting product was a viscous oil and was distilled at 120°C for 10 min. Final isolation gave 497 mg (1.65 mmol, 60% yield) of the target compound. The 1H NMR (400 MHz, CDCl3) data of the product were as follows: δ 7.62 (s, 1H), 7.43 (s, 1H), 7.18 (s, 1H), 3.82 (s, 3H), 1.32 (s, 12H).

References

[1] Journal of the American Chemical Society, 2018,
[2] Tetrahedron, 2008, vol. 64, # 29, p. 6824 - 6830
[3] Patent: US2016/168151, 2016, A1. Location in patent: Paragraph 0241
[4] Angewandte Chemie - International Edition, 2002, vol. 41, # 16, p. 3056 - 3058
[5] Organic Letters, 2007, vol. 9, # 5, p. 757 - 760

2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane Suppliers

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479411-93-3, 2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolaneRelated Search:

2-(3-Methoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

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1,3,2-Dioxaborolane, 2-[3-methoxy-5-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-

479411-93-3