N-Methoxy-N,2-dimethylpropanamide
- Product Name
- N-Methoxy-N,2-dimethylpropanamide
- CAS No.
- 113778-69-1
- Chemical Name
- N-Methoxy-N,2-dimethylpropanamide
- Synonyms
- N-Methoxy-N-MethylisobutyraMide;N-Methoxy-N,2-dimethylpropanamide;Propanamide, N-methoxy-N,2-dimethyl-;N-Methoxy-2-methyl-N-methylpropanamide;N-METHOXY-N,2-DIMETHYLPROPANAMIDE(WX619185)
- CBNumber
- CB72565294
- Molecular Formula
- C6H13NO2
- Formula Weight
- 131.17
- MOL File
- 113778-69-1.mol
N-Methoxy-N,2-dimethylpropanamide Property
- Boiling point:
- 137.7±23.0 °C(Predicted)
- Density
- 0.945±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, DCM, Ethyl Acetate
- form
- Oil
- color
- Colourless
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- M263050
- Product name
- N-Methoxy-N-methylisobutyramide
- Packaging
- 25g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CHM0096683
- Product name
- N-METHOXY-N-METHYLISOBUTYRAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.55
- Updated
- 2021/12/16
- Product number
- OR959864
- Product name
- N-Methoxy-N,2-dimethylpropanamide
- Packaging
- 25g
- Price
- $649
- Updated
- 2021/12/16
- Product number
- 71285
- Product name
- N-Methoxy-N-methylisobutyramide
- Packaging
- 5G
- Price
- $750
- Updated
- 2021/12/16
- Product number
- OR959864
- Product name
- N-Methoxy-N,2-dimethylpropanamide
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
N-Methoxy-N,2-dimethylpropanamide Chemical Properties,Usage,Production
Uses
N-Methoxy-N-methylisobutyramide is an intermediate in the synthesis of pteridine derivatives with potential protective effects with vibrio cholerae infection.
Synthesis
6638-79-5
79-30-1
113778-69-1
I. Synthesis of N-methoxy-N,2-dimethylpropionamide. Isobutyryl chloride (6.02 mL, 57.5 mmol) was added slowly and dropwise to a solution of N,O-dimethylhydroxylamine hydrochloride (5.61 g, 57.5 mmol) and triethylamine (17.6 mL, 126.5 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was washed with deionized water (100 mL) and the organic layer was dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the crude product was purified by silica gel column chromatography (eluent: n-hexane to 9:1 n-hexane/ethyl acetate) to afford N-methoxy-N,2-dimethylpropanamide (5.55 g, 74% yield).1H NMR (300 MHz, DMSO-d6) δ 3.72 (s, 3H), 3.31 (m, 1H), 3.18 (s, 3H) 1.09 (d, J = 6.87 Hz, 6H).
References
[1] Organic Letters, 2012, vol. 14, # 9, p. 2250 - 2253
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 7, p. 3117 - 3130
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 4840 - 4860
[4] Chemistry - A European Journal, 2017, vol. 23, # 57, p. 14345 - 14357
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 20, p. 3337 - 3340
N-Methoxy-N,2-dimethylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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