Methyl 2-fluoro-5-hydroxybenzoate

Product Name: Methyl 2-fluoro-5-hydroxybenzoate
CAS No.: 1084801-91-1
Chemical Name: Methyl 2-fluoro-5-hydroxybenzoate
Synonyms: Methyl Salicylate Impurity 18;Methyl 2-fluoro-5-hydroxybenzoate;Benzoic acid, 2-fluoro-5-hydroxy-, methyl ester
CBNumber: CB72565603
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: 1084801-91-1.mol

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Methyl 2-fluoro-5-hydroxybenzoate Property

Melting point:: 88-90°
Boiling point:: 290.7±25.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.16±0.18(Predicted)
form: solid
color: Beige

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Safety

HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Oakwood

Product number: 223280
Product name: Methyl2-fluoro-5-hydroxybenzoate
Purity: 98%
Packaging: 1g
Price: $30
Updated: 2021/12/16

Apolloscientific

Product number: PC49647
Product name: Methyl 2-fluoro-5-hydroxybenzoate
Packaging: 1g
Price: $68
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-3-27
Product name: Methyl 2-fluoro-5-hydroxybenzoate
Purity: 95%
Packaging: 1g
Price: $80
Updated: 2021/12/16

Oakwood

Product number: 223280
Product name: Methyl2-fluoro-5-hydroxybenzoate
Purity: 98%
Packaging: 5g
Price: $125
Updated: 2021/12/16

Apolloscientific

Product number: PC49647
Product name: Methyl2-fluoro-5-hydroxybenzoate
Packaging: 5g
Price: $147
Updated: 2021/12/16

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Methyl 2-fluoro-5-hydroxybenzoate Chemical Properties,Usage,Production

Synthesis

67-56-1

51446-30-1

1084801-91-1

General procedure for the synthesis of methyl 2-fluoro-5-hydroxybenzoate from methanol and 2-fluoro-5-hydroxybenzoic acid: 2-fluoro-5-hydroxybenzoic acid (3e) (780 mg, 5 mmol) was dissolved in 100 mL of methanol. Thionyl chloride (0.8 mL, 10 mmol) was added slowly and dropwise in an ice bath (0 °C) and under stirring conditions, followed by refluxing the reaction mixture for 2 hours. After completion of the reaction, the reaction solution was concentrated and purified by column chromatography (eluent ratio of petroleum ether: ethyl acetate = 2:1) to afford methyl 2-fluoro-5-hydroxybenzoate (3f) 833 mg as a white solid in 98% yield. The product was characterized by 1H NMR (600 MHz, DMSO-d6): δ 9.73 (s, 1H), 7.20-7.18 (m, 1H), 7.13-7.09 (m, 1H), 6.99-6.97 (m, 1H), 3.80 (s, 3H); ESI-MS m/z: calculated value 170.04, measured value 171.25 [M + H]+.

References

[1] Patent: WO2018/5336, 2018, A1. Location in patent: Page/Page column 98
[2] Patent: EP2799435, 2014, A1. Location in patent: Paragraph 0051; 0065; 0067
[3] Patent: US2015/51211, 2015, A1. Location in patent: Paragraph 0091; 0093
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3141 - 3147

Methyl 2-fluoro-5-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-fluoro-5-hydroxybenzoate Suppliers

Canada 1 China 52 India 3 United Kingdom 1 United States 7 Global 64

Shanghai Hanhong Scientific Co.,Ltd.

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SynAsst Chemical.

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Cochemical Ltd.

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Bide Pharmatech Ltd.

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Tianjin Anhao Biological Technology Co., Ltd.

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Changzhou Anxuan Chemical, Co., Ltd.

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Amadis Chemical Company Limited

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Hubei Yangxin Medical Technology Co., Ltd.

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1084801-91-1, Methyl 2-fluoro-5-hydroxybenzoateRelated Search:

Methyl 2-fluoro-5-hydroxybenzoate

Benzoic acid, 2-fluoro-5-hydroxy-, methyl ester

Methyl Salicylate Impurity 18

1084801-91-1