AR-M 1000390 hydrochloride

Product Name: AR-M 1000390 hydrochloride
CAS No.: 209808-47-9
Chemical Name: AR-M 1000390 hydrochloride
Synonyms: ARM-390;ARM-390HCl;AR-M1000390 HCl;ARM390 Hydrochloride;ARM 390;ARM-390;ARM390;AR-M 1000390 hydrochloride;N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride;N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride;Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride;N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)
CBNumber: CB72565926
Molecular Formula: C23H29ClN2O
Formula Weight: 384.95
MOL File: 209808-47-9.mol

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AR-M 1000390 hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: <38.49mg/ml in DMSO; <38.49mg/ml in H2O
form: solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4335
Product name: AR-M1000390hydrochloride
Purity: ≥97%(HPLC)
Packaging: 10
Price: $193
Updated: 2021/12/16

Usbiological

Product number: 254661
Product name: AR-M 1000390 hydrochloride
Packaging: 10mg
Price: $438
Updated: 2021/12/16

TRC

Product number: D444820
Product name: N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamideHydrochloride
Packaging: 50mg
Price: $605
Updated: 2021/12/16

AK Scientific

Product number: 9731DX
Product name: AR-M1000390hydrochloride
Packaging: 50mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0020750
Product name: AR-M1000390hydrochloride
Purity: 99.80%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

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AR-M 1000390 hydrochloride Chemical Properties,Usage,Production

Uses

N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride is a (arylheteroaryl)methylene]piperidine derivatives with analgesic effect.

Biological Activity

ar-m 1000390 hydrochloride is a potent and selective agonist of δ-opioid receptor with ic50 value of 0.87 nm [1].opioid receptor is a g protein-coupled receptor with opioids as ligands. δ-opioid receptor is a opioid receptor with enkephalins as its endogenous ligands and activation of δ-opioid receptor causes analgesia.ar-m 1000390 hydrochloride is a potent and selective δ-opioid receptor agonist with ic50 values of 0.87 nm, 3.8 and 7.47 μm for δ-opioid receptor, μ-opioid receptor and κ-opioid receptor, respectively [1]. in the sk-n-be neuroblastoma cell line, ar-m 1000390 inhibited forskolin-stimulated camp accumulation with ki and ec50 values of 106 and 111 nm, respectively. sustained activation of opioid receptors by ar-m1000390 produced a strong desensitization [2].in dor-egfp mice, arm390 (10 mg/kg) significantly reduced cfa-induced heat hyperalgesia at day 1 and induced complete tolerance at day 5. in arm390-tolerant mice, δ-opioid receptor uncoupled to ca2+ channels in dorsal root ganglia [3].

storage

Store at -20°C

References

[1]. wei zy, brown w, takasaki b, et al. n,n-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. j med chem, 2000, 43(21): 3895-3905.
[2]. marie n, landemore g, debout c, et al. pharmacological characterization of ar-m1000390 at human delta opioid receptors. life sci, 2003, 73(13): 1691-1704.
[3]. pradhan aa, walwyn w, nozaki c, et al. ligand-directed trafficking of the -opioid receptor in vivo: two paths toward analgesic tolerance. j neurosci, 2010, 30(49): 16459-16468.

AR-M 1000390 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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AR-M 1000390 hydrochloride Suppliers

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View Lastest Price from AR-M 1000390 hydrochloride manufacturers

Career Henan Chemical Co

Product: AR-M 1000390 hydrochloride 209808-47-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

209808-47-9, AR-M 1000390 hydrochlorideRelated Search:

AR-M 1000390 hydrochloride

N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride

ARM-390HCl

ARM-390

ARM 390;ARM-390;ARM390

N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)

N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride

ARM390 Hydrochloride

AR-M1000390 HCl

Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride

Inhibitor,inhibit,AR-M 1000390,AR M 1000390 hydrochloride,Opioid Receptor,ARM 1000390 hydrochloride

209808-47-9

C23H28N2OHCl

API

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