2-FLUOROPALMITIC ACID
- Product Name
- 2-FLUOROPALMITIC ACID
- CAS No.
- 16518-94-8
- Chemical Name
- 2-FLUOROPALMITIC ACID
- Synonyms
- 2-FLUOROPALMITIC ACID;2-FLUOROHEXADECANOIC ACID;JGRIJJOLCNCSNX-UHFFFAOYSA-N;Hexadecanoic acid, 2-fluoro-
- CBNumber
- CB7256741
- Molecular Formula
- C16H31FO2
- Formula Weight
- 274.41
- MOL File
- 16518-94-8.mol
2-FLUOROPALMITIC ACID Property
- Boiling point:
- 376.1±12.0 °C(Predicted)
- Density
- 0.936±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 2.70±0.21(Predicted)
N-Bromosuccinimide Price
- Product number
- 90380
- Product name
- 2-fluoro Palmitic Acid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 90380
- Product name
- 2-fluoro Palmitic Acid
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 90380
- Product name
- 2-fluoro Palmitic Acid
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $272
- Updated
- 2024/03/01
- Product number
- 90380
- Product name
- 2-fluoro Palmitic Acid
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $513
- Updated
- 2024/03/01
- Product number
- C3924
- Product name
- 2-fluoroPalmiticAcid
- Packaging
- 50mg
- Price
- $432
- Updated
- 2021/12/16
2-FLUOROPALMITIC ACID Chemical Properties,Usage,Production
Definition
ChEBI: 2-fluorohexadecanoic acid is a long-chain fatty acid and a fluoro fatty acid.
Biological Activity
2-fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-coa synthetase [1]. the length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-coa synthetases (acs).mammalian long-chain acyl-coa synthetases (acsl) activate fatty acids with chain lengths of 12 to 20 carbon atoms. the long-chain acyl-coa synthetase mrna is expressed virtually in heart, liver, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung [2].palmitic acid was a selective cytotoxic substance extracted from the marine algal. at concentrations ranging from 12.5 to 50 μg/ml, palmitic acid showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal hdf cells. palmitic acid (50 μg/ml) induced apoptosis in the human leukemic cell line molt-4. palmitic acid also showed in vivo antitumor activity in mice [3]. 2-fluoropalmitic acid showed an inhibitory effect on sphingosine biosynthesis and long-chain acyl-coa synthetase with an ic50 value of 0.2 mm [1].
References
[1] soltysiak r m, matsuura f, bloomer d, et al. d, l-α-fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells[j]. biochimica et biophysica acta (bba)-lipids and lipid metabolism, 1984, 792(2): 214-226.
[2] suzuki h, kawarabayasi y, kondo j, et al. structure and regulation of rat long-chain acyl-coa synthetase[j]. journal of biological chemistry, 1990, 265(15): 8681-8685.
[3] harada h, yamashita u, kurihara h, et al. antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga[j]. anticancer research, 2001, 22(5): 2587-2590.
2-FLUOROPALMITIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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